INT252878

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Grip2) plasma membrane (Prkaca, Grip2) nucleoplasm (Prkaca)
mitochondrion (Prkaca) endoplasmic reticulum (Grip2) Golgi apparatus (Prkaca)
Anatomy Link Frequency
neurons 2
Prkaca (Rattus norvegicus)
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal column 62 99.14 Very High Very High Very High
Pain 6 97.96 Very High Very High Very High
antagonist 7 92.32 High High
nMDA receptor 5 88.64 High High
central sensitization 1 86.96 High High
Glutamate receptor 4 83.24 Quite High
Visceral pain 26 79.12 Quite High
Spinal cord 22 75.28 Quite High
intrathecal 4 69.56 Quite High
Kinase C 9 54.08 Quite High
Disease Link Frequency Relevance Heat
Nociception 33 79.44 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 79.12 Quite High
Pain 4 43.88 Quite Low
Targeted Disruption 1 20.88 Low Low
INFLAMMATION 4 12.36 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Dyspepsia 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To combine the finding of the increased expression of PKA in PSDC neurons, we could suggest that a possible role for PKA in regulation of AMPA receptor activity in PSDC neurons during visceral painful states.
PKA Spec (possible) Regulation (role) of Spec (possible) Regulation (regulation) of AMPA in neurons associated with pain and dorsal column
1) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.08 Pain Relevance 0.94

General Comments

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