INT253069

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1)
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 94.72 High High
Pain 4 91.52 High High
Potency 1 90.88 High High
tolerance 1 86.96 High High
Spinal cord 1 80.16 Quite High
Paracetamol 3 73.40 Quite High
agonist 4 50.00 Quite Low
Inflammation 14 39.20 Quite Low
cytokine 50 28.88 Quite Low
antagonist 3 25.88 Quite Low
Disease Link Frequency Relevance Heat
Pain 3 91.52 High High
Neurodegenerative Disease 2 90.44 High High
Hematological Disease 6 87.24 High High
Bordatella Infection 1 78.60 Quite High
Hyperalgesia 2 77.28 Quite High
Cancer 14 74.04 Quite High
Diphtheria 7 70.88 Quite High
Fever 2 69.76 Quite High
Death 3 64.64 Quite High
Apoptosis 2 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The list of biological activities associated with Bv8/PROK peptides is rapidly growing.
PROK Binding (associated) of
1) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.14 Pain Relevance 0.04
Prokineticins bind to two closely related G-protein coupled receptors, known as prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2), with both receptors able to bind PROK1 and PROK2 with similar affinities (Soga et al., 2002).
PROK1 Binding (bind) of
2) Confidence 0.33 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.27 Pain Relevance 0.09
Activation of ERK 1 and 2 through PK1–PKR1 binding has been demonstrated, by use of specific inhibitors, to be important in PK1-induced proliferation and migration of ACE cells [17].


PK1 Binding (binding) of
3) Confidence 0.28 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.08 Pain Relevance 0.05
This optimized fusion protein toxin binds to a high- or intermediate-affinity receptor.27,28 Intermediate affinity receptors have beta (CD122) and gamma (CD132) subunits and bind IL2 with Kd ?
protein toxin Binding (binds) of
4) Confidence 0.01 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.40 Pain Relevance 0.16

General Comments

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