INT253386

Context Info Confidence 0.07 First Reported 2008 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 7 Disease Relevance 1.37 Pain Relevance 0.11

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)

Anatomy Link Frequency myocardium 1 hypothalamus 1 Eif4ebp1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Intracerebroventricular 15 97.44 Inflammation 3 81.24 agonist 6 14.40 cytokine 13 5.00 anesthesia 7 5.00 nalbuphine 3 5.00 Spinal cord 3 5.00 analgesia 3 5.00 ketamine 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Obesity 118 98.36 Hyperglycemia 2 90.72 Diabetes Mellitus 7 90.00 Appetite Loss 42 89.44 Hyperplasia 4 82.56 INFLAMMATION 3 81.24 Cardiovascular Disease 2 80.80 Insulin Resistance 2 76.00 Neointima 11 19.00 Injury 16 17.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, while levels of p70 S6K and 4E-BP1 were not examined as part of the previous study, phosphorylation of other downstream targets of AKT kinase activity, namely Foxo1 and Foxo3, were shown to be similarly reduced.

Spec (examined) Gene_expression (levels) of 4E-BP1

1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

AMPK, ACC, p70S6K and 4EBP1 protein expression (Figures 4b–e, lower panels).

Gene_expression (expression) of 4EBP1

2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.07

6 M) to rats pretreated with AICAR reduced both p70S6K and 4EBP1 phosphorylation levels in the hypothalamus.

Gene_expression (levels) of 4EBP1 in hypothalamus

3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0

The p70S6K and 4EBP1 protein levels were not different between the groups (Figures 7e and f, lower panels).

Gene_expression (levels) of 4EBP1

4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.72 Pain Relevance 0

In contrast, elevations in phosphorylation of p70 S6K residues Thr421/Ser424, and 4E-BP1 residues Thr37/Thr46 (P<0.05), consistent with an elevation in translation initiation, were seen exclusively in the myocardium of LPS-treated animals.

Gene_expression (residues) of 4E-BP1 in myocardium

5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

Protein and phosphorylation levels of AKT, p70 S6K and 4E-BP1

Gene_expression (levels) of 4E-BP1

6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0

Insulin induces increased expression of translation initiation factors and phosphorylation of 4EBP-1 and S6K, critical cell cycle regulators downstream of mTOR.

Gene_expression (expression) of 4EBP-1

7) Confidence 0.02 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.65 Pain Relevance 0.04

General Comments

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