INT253406

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
plasma 2
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 11 98.38 Very High Very High Very High
Body Weight 21 90.80 High High
Hyperphagia 3 83.44 Quite High
Appetite Loss 20 83.12 Quite High
Obesity 39 76.32 Quite High
Aging 1 56.40 Quite High
Ketosis 5 5.00 Very Low Very Low Very Low
Body Weight Changes 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low
Starvation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas KD rats had significantly increased fat pad weights and plasma leptin levels as compared to CH rats, resuming the chow diet prevented a further increase in adiposity and leptin over time.
Negative_regulation (prevented) of Positive_regulation (increase) of leptin in plasma associated with peripheral arterial disease
1) Confidence 0.41 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2781796 Disease Relevance 0.45 Pain Relevance 0
Next, we investigated whether the increased sensitivity of the leptin action on food intake induced by exercise, could be due to the modulation of AMPK activity.
Negative_regulation (modulation) of Positive_regulation (induced) of leptin
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.29 Pain Relevance 0

General Comments

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