INT253474

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca, Bcl2) cytoplasm (Prkaca, Bcl2) nucleus (Prkaca, Bcl2)
cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2) Golgi apparatus (Prkaca)
Prkaca (Mus musculus)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 49.84 Quite Low
Inflammation 12 49.20 Quite Low
cOX1 2 44.44 Quite Low
COX2 16 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 20 100.00 Very High Very High Very High
Necrosis 54 91.68 High High
Mycobacterial Infection 96 83.72 Quite High
Apoptosis 32 83.44 Quite High
Fever 1 54.20 Quite High
Pressure And Volume Under Development 2 53.80 Quite High
Increased Venous Pressure Under Development 2 50.48 Quite High
Pain 1 49.84 Quite Low
INFLAMMATION 14 49.20 Quite Low
Infection 61 14.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKA activation was found to block cell death by phosphorylation of the proapoptotic protein Bad (49, 50, 54), causing its inactivation, and also increases the expression of Bcl-2 involving the CREB (cAMP responsive element-binding) protein and inhibition of cell death (59).
Positive_regulation (activation) of PKA Positive_regulation (increases) of Gene_expression (expression) of Bcl-2 associated with death
1) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.27 Pain Relevance 0

General Comments

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