INT253488

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2, Ptger4, Pik3r1) plasma membrane (Ptger2, Ptger4, Pik3r1) signal transducer activity (Ptger2, Ptger4)
intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
Ptger2 (Mus musculus)
Ptger4 (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 64.48 Quite High
Inflammation 12 63.84 Quite High
cOX1 2 59.08 Quite High
COX2 16 14.80 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 96 98.36 Very High Very High Very High
Apoptosis 32 98.08 Very High Very High Very High
Necrosis 54 96.56 Very High Very High Very High
Death 20 79.28 Quite High
Fever 1 68.84 Quite High
Pressure And Volume Under Development 2 68.44 Quite High
Increased Venous Pressure Under Development 2 65.12 Quite High
Pain 1 64.48 Quite High
INFLAMMATION 14 63.84 Quite High
Infection 61 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PGE2 stimulation of the EP4 receptor triggers activation of PI3K and of Akt (48), blockade of mitochondrial damage by PGE2 critical for prevention of necrosis is mediated through the EP2 receptor.
PGE2 Positive_regulation (stimulation) of EP4 receptor Positive_regulation (triggers) of Positive_regulation (activation) of PI3K associated with necrosis
1) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.20 Pain Relevance 0.13

General Comments

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