INT253564

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Sp1) DNA binding (Sp1) cytoplasm (Sp1)
lipid metabolic process (Lpl) extracellular space (Lpl) extracellular region (Lpl)
Lpl (Mus musculus)
Sp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 26 99.70 Very High Very High Very High
Inflammation 8 64.36 Quite High
IPN 2 48.32 Quite Low
Pain 2 45.36 Quite Low
Inflammatory response 6 42.68 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 22 88.96 High High
Obesity 4 78.84 Quite High
Diabetes Mellitus 2 78.36 Quite High
Disorder Of Lipid Metabolism 4 70.48 Quite High
INFLAMMATION 14 64.36 Quite High
Cancer 2 58.72 Quite High
Necrosis 2 58.16 Quite High
Disease 6 54.32 Quite High
Renal Disease 2 50.56 Quite High
Inflammatory Pain 2 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediated via phosphorylation of Sp1 (and possibly Sp3), which leads to decreased binding to regulatory sequences in the LPL gene.
LPL gene Binding (binding) of Sp1
1) Confidence 0.13 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.42 Pain Relevance 0.09
whereby the cytokine decreases the binding of Sp1 and Sp3 to three conserved recognition sequences in the regulatory region of the LPL gene [9].
LPL gene Binding (binding) of Sp1 associated with cytokine
2) Confidence 0.13 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.48 Pain Relevance 0.05

General Comments

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