INT253982

Context Info Confidence 0.45 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.85 Pain Relevance 2.60

extracellular space (Cxcl12) plasma membrane (Cxcl12)

Cxcl12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Lasting pain 3 98.68 Stimulus evoked pain 6 96.12 chemokine 57 95.96 dorsal root ganglion 12 84.68 substance P 3 80.84 Inflammation 99 60.64 cytokine 18 5.00 halothane 6 5.00 Arthritis 6 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Cystitis 51 99.84 Pain 9 98.68 Hypersensitivity 6 95.92 Neuropathic Pain 3 87.00 Ganglion Cysts 12 84.68 Injury 18 67.64 INFLAMMATION 102 60.64 Colon Cancer 3 57.72 Inflammatory Bowel Disease 3 56.44 Body Weight 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.

Spec (may) Positive_regulation (activation) of SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis

1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.29 Pain Relevance 0.86

In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.

Positive_regulation (upregulated) of SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis

2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.27 Pain Relevance 0.85

In CYP-induced cystitis, then, activation of CXCR4 receptors, either by its recognized ligand SDF-1 (upregulated as a result of CYP) or due to interaction with MIF (also upregulated as a result of CYP and present in greater quantities than SDF-1) may in fact be contributing to pain hypersensitivity.

Positive_regulation (upregulated) of SDF-1 Binding (recognized) of associated with hypersensitivity, stimulus evoked pain and cystitis

3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.29 Pain Relevance 0.89

General Comments

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