INT253994

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.96
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1, Mif) isomerase activity (Mif) endoplasmic reticulum (Cyp3a23/3a1)
cytoplasm (Mif) cell proliferation (Mif) extracellular space (Mif)
Anatomy Link Frequency
urine 2
Cyp3a23/3a1 (Rattus norvegicus)
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 100.00 Very High Very High Very High
chemokine 38 95.40 Very High Very High Very High
Inflammation 66 90.36 High High
cytokine 12 82.24 Quite High
Stimulus evoked pain 4 74.92 Quite High
Lasting pain 2 62.88 Quite High
dorsal root ganglion 8 48.88 Quite Low
substance P 2 45.04 Quite Low
halothane 4 19.76 Low Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 68 100.00 Very High Very High Very High
Cystitis 34 79.72 Quite High
Hypersensitivity 4 74.92 Quite High
Pain 6 74.24 Quite High
Neuropathic Pain 2 51.20 Quite High
Ganglion Cysts 8 48.88 Quite Low
Injury 12 43.64 Quite Low
Weight Loss 2 31.76 Quite Low
Colon Cancer 2 21.92 Low Low
Inflammatory Bowel Disease 2 20.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCR4 and MIF are co-localized in cells in the urothelium and CYP induced co-localization of CXCR4 and MIF to superficial cells of the urothelium.
CYP Positive_regulation (induced) of Localization (localization) of MIF
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.58 Pain Relevance 0.45
This raises the possibility that these cells will be activated by MIF present in the urine and in fact, CYP (present study) and other inflammatory stimuli [8]–[10] increase luminal MIF release.
CYP Positive_regulation (increase) of Localization (release) of MIF in urine associated with inflammatory stimuli
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.38 Pain Relevance 0.23

General Comments

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