INT254252

Context Info Confidence 0.76 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 7.17 Pain Relevance 1.49

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)

Anatomy Link Frequency bone marrow 1 fibroblasts 1 corneas 1 granulation 1 hippocampus 1 Cxcl12 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 50 99.80 Inflammation 65 99.60 cytokine 14 98.52 Hippocampus 35 96.24 chemokine 96 94.12 Inflammatory response 4 77.40 tolerance 2 74.00 Multiple sclerosis 2 68.48 Spinal cord 2 66.88 cerebral cortex 1 56.08

Disease Link Frequency Relevance Heat Carcinoma 100 99.86 Rheumatoid Arthritis 50 99.80 INFLAMMATION 69 99.60 Adhesions 144 99.28 Apoptosis 186 99.06 Injury 194 95.24 Diabetes Mellitus 38 94.96 Convulsion 44 93.44 Death 33 88.56 Status Epilepticus 19 88.48

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The loss of adhesion coincides with increased levels of secreted CXCL12 over that same time span, from not detectable at day 0 to a maximum after 4-days in culture (data not shown).

Localization (secreted) of CXCL12 associated with adhesions

1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.09 Pain Relevance 0.08

Lentiviral transduction with shRNA to Bim, scrambled transcript, or empty (mock) vectors did not modulate ligand or receptor transcript expression (Figure 6C) nor CXCL12 secretion (Figure 6D) in our colonic carcinoma cell lines.

Localization (secretion) of CXCL12 associated with carcinoma

2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.54 Pain Relevance 0

As a first step, we examined activity levels of the extrinsic apoptotic initiator, caspase-8, and intrinsic apoptotic initiator caspase-9 levels in carcinoma cells secreting varying amounts of CXCL12 (Hi, Med, Low) [24].

Localization (secreting) of CXCL12 associated with carcinoma and apoptosis

3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.49 Pain Relevance 0

These data suggest that a localized source of CXCL12 may direct the migration of ESNPs towards specific regions of neurodegeneration in the adult hippocampus.

Localization (localized) of CXCL12 in hippocampus associated with hippocampus

4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.65 Pain Relevance 0.36

Fluorescence microscopy confirmed that the reduced adherence of GFP control cells on inserts was not a function of chemotactic emigration toward CXCL12 secreting cells (data not shown).

Localization (secreting) of CXCL12

5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.22 Pain Relevance 0.07

In corneas, the infiltration of SDF1-positive inflammatory cells (Figure 4) and the expression of SDF1 and TNF-?

Localization (infiltration) of SDF1 in corneas associated with inflammation

6) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 0.89 Pain Relevance 0.22

However, direct application of SDF-1/CXCL12 enhances mobilization of EPCs and improves healing, specifically enhancing recruitment of Cd34+ EPCs into the neovasculature of granulation tissue [39, 42].

Localization (application) of CXCL12 in granulation

7) Confidence 0.48 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.44 Pain Relevance 0.19

, erythropoietin and stromal cell-derived factor-1, while dermal fibroblasts secreted greater amounts of pro-inflammatory cytokines such as interleukin-6 [31].

Localization (secreted) of stromal cell-derived factor-1 in fibroblasts associated with inflammation and cytokine

8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743192 Disease Relevance 0.26 Pain Relevance 0.35

Also, the inflamed RA synovium releases CXCL12 (SDF-1), interleukin-6, TNF, BAFF (B-cell activating factor of TNF family), and APRIL (a proliferation-inducing ligand), all known to promote the accumulation and survival of long-lived plasma cells, which are normally found mainly in bone marrow [25].

Localization (releases) of CXCL12 in bone marrow associated with rheumatoid arthritis

9) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.58 Pain Relevance 0.22

General Comments

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