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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.17
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
bone marrow 1
fibroblasts 1
corneas 1
granulation 1
hippocampus 1
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 50 99.80 Very High Very High Very High
Inflammation 65 99.60 Very High Very High Very High
cytokine 14 98.52 Very High Very High Very High
Hippocampus 35 96.24 Very High Very High Very High
chemokine 96 94.12 High High
Inflammatory response 4 77.40 Quite High
tolerance 2 74.00 Quite High
Multiple sclerosis 2 68.48 Quite High
Spinal cord 2 66.88 Quite High
cerebral cortex 1 56.08 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 100 99.86 Very High Very High Very High
Rheumatoid Arthritis 50 99.80 Very High Very High Very High
INFLAMMATION 69 99.60 Very High Very High Very High
Adhesions 144 99.28 Very High Very High Very High
Apoptosis 186 99.06 Very High Very High Very High
Injury 194 95.24 Very High Very High Very High
Diabetes Mellitus 38 94.96 High High
Convulsion 44 93.44 High High
Death 33 88.56 High High
Status Epilepticus 19 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of adhesion coincides with increased levels of secreted CXCL12 over that same time span, from not detectable at day 0 to a maximum after 4-days in culture (data not shown).
Localization (secreted) of CXCL12 associated with adhesions
1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.09 Pain Relevance 0.08
Lentiviral transduction with shRNA to Bim, scrambled transcript, or empty (mock) vectors did not modulate ligand or receptor transcript expression (Figure 6C) nor CXCL12 secretion (Figure 6D) in our colonic carcinoma cell lines.
Localization (secretion) of CXCL12 associated with carcinoma
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.54 Pain Relevance 0
As a first step, we examined activity levels of the extrinsic apoptotic initiator, caspase-8, and intrinsic apoptotic initiator caspase-9 levels in carcinoma cells secreting varying amounts of CXCL12 (Hi, Med, Low) [24].
Localization (secreting) of CXCL12 associated with carcinoma and apoptosis
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.49 Pain Relevance 0
These data suggest that a localized source of CXCL12 may direct the migration of ESNPs towards specific regions of neurodegeneration in the adult hippocampus.
Localization (localized) of CXCL12 in hippocampus associated with hippocampus
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.65 Pain Relevance 0.36
Fluorescence microscopy confirmed that the reduced adherence of GFP control cells on inserts was not a function of chemotactic emigration toward CXCL12 secreting cells (data not shown).
Localization (secreting) of CXCL12
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.22 Pain Relevance 0.07
In corneas, the infiltration of SDF1-positive inflammatory cells (Figure 4) and the expression of SDF1 and TNF-?
Localization (infiltration) of SDF1 in corneas associated with inflammation
6) Confidence 0.57 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2751803 Disease Relevance 0.89 Pain Relevance 0.22
However, direct application of SDF-1/CXCL12 enhances mobilization of EPCs and improves healing, specifically enhancing recruitment of Cd34+ EPCs into the neovasculature of granulation tissue [39, 42].
Localization (application) of CXCL12 in granulation
7) Confidence 0.48 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.44 Pain Relevance 0.19
, erythropoietin and stromal cell-derived factor-1, while dermal fibroblasts secreted greater amounts of pro-inflammatory cytokines such as interleukin-6 [31].
Localization (secreted) of stromal cell-derived factor-1 in fibroblasts associated with inflammation and cytokine
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743192 Disease Relevance 0.26 Pain Relevance 0.35
Also, the inflamed RA synovium releases CXCL12 (SDF-1), interleukin-6, TNF, BAFF (B-cell activating factor of TNF family), and APRIL (a proliferation-inducing ligand), all known to promote the accumulation and survival of long-lived plasma cells, which are normally found mainly in bone marrow [25].
Localization (releases) of CXCL12 in bone marrow associated with rheumatoid arthritis
9) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.58 Pain Relevance 0.22

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