INT254306

Context Info Confidence 0.03 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.26 Pain Relevance 0.08

Anatomy Link Frequency lymphocyte 1 TNFRSF13B (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 2 86.60 antagonist 5 66.96 Angina 3 5.00 methotrexate 2 5.00 rheumatoid arthritis 2 5.00 headache 2 5.00 Central nervous system 1 5.00 withdrawal 1 5.00 cINOD 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Necrosis 2 84.80 Targeted Disruption 1 84.56 Cancer 2 84.44 Systemic Lupus Erythematosus 50 82.16 Disease 26 79.36 Hypergammaglobulinemia 1 76.72 Renal Disease 4 72.48 Proteinuria 1 62.88 Autoimmune Disease 1 50.20 Neutropenia 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The biologically active, soluble form of BLyS is enzymatically cleaved from the cell membrane and can bind to any of three receptors: TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) [7]; BCMA (B-cell Maturation Antigen) [8]; and BAFF-R (B-cell lymphocyte activating factor receptor)/BLyS receptor 3 [9,10], localized primarily on B lymphocytes.

Localization (localized) of TACI in lymphocyte

1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.26 Pain Relevance 0.08

General Comments

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