INT25465

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Context Info
Confidence 0.15
First Reported 1989
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.59
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ISL1) cytoplasm (ISL1)
Anatomy Link Frequency
pancreatic islet 1
neuronal 1
amacrine cells 1
ISL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 86.32 High High
anesthesia 2 83.76 Quite High
Action potential 8 81.44 Quite High
Somatostatin 5 65.68 Quite High
conotoxin 12 63.96 Quite High
tolerance 4 44.28 Quite Low
imagery 3 34.20 Quite Low
gABA 9 32.24 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
tetrodotoxin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Islet Cell Adenoma 29 100.00 Very High Very High Very High
Diabetes Mellitus 53 99.88 Very High Very High Very High
Cancer 64 99.44 Very High Very High Very High
Ganglion Cysts 24 94.60 High High
Fibrosarcoma 2 93.60 High High
Insulinoma 2 89.92 High High
Carcinoid 5 87.76 High High
Obesity 7 87.60 High High
Hyperglycemia 8 86.92 High High
Leukemia 2 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No increase in anticytoplasmic islet cell antibody titer was detected during the year of observation following transplantation.
Neg (No) Positive_regulation (increase) of islet
1) Confidence 0.15 Published 1989 Journal J Diabet Complications Section Abstract Doc Link 2526136 Disease Relevance 0.24 Pain Relevance 0.08
To test whether homeodomain transcription factors in addition to Islet1 are expressed by developing cholinergic amacrine cells, we double-labeled sections with antibodies to ChAT and Pax6, AP2?
Spec (whether) Positive_regulation (factors) of Islet1 in amacrine cells
2) Confidence 0.09 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.22 Pain Relevance 0
Associated with the tumour were nests of cells with a pancreatic islet morphology, which expressed general neuroendocrine markers (CD56, synatophysin and chromogranin), and specific islet cell markers insulin and glucagon.
Positive_regulation (pancreatic) of islet in pancreatic islet associated with cancer
3) Confidence 0.05 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2709896 Disease Relevance 1.18 Pain Relevance 0.04
Genes not previously described in islet cell tumors, but exhibiting elevated specific expression, include the AXL receptor tyrosine kinase (AXL) and the transcription factor V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB).
Neg (not) Positive_regulation (described) of islet associated with fibrosarcoma and islet cell adenoma
4) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.10 Pain Relevance 0.03
-cell glucagon secretion by neuronal factors and by paracrine factors from neighbouring cells, including the important islet hormone insulin.
Positive_regulation (important) of islet in neuronal
5) Confidence 0.02 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1868042 Disease Relevance 0.09 Pain Relevance 0.10
Intraperitoneal injection of recombinant Pdx-1 into streptozotocin-induced diabetic mice increased islet cell numbers and proliferation in pancreata [32].
Positive_regulation (increased) of islet associated with diabetes mellitus
6) Confidence 0.01 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.53 Pain Relevance 0
Such an acceleration of the islet cell maturation process, induced by 9-day SC coculture, and substantiated by functional insulin data, was observed [5].
Positive_regulation (induced) of islet
7) Confidence 0.01 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0.23 Pain Relevance 0

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