INT254867

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ctgf, Serpine1) extracellular region (Ctgf, Serpine1) cell differentiation (Ctgf)
cytosol (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Ctgf (Mus musculus)
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 52.28 Quite High
cytokine 2 47.36 Quite Low
agonist 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 51 96.36 Very High Very High Very High
Atherosclerosis 35 91.88 High High
INFLAMMATION 7 52.28 Quite High
Rupture 1 33.04 Quite Low
Death 15 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 3 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 3 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Cardiovascular Disease 2 5.00 Very Low Very Low Very Low
Neointima 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data in cultured VSMCs show that statins upregulate the profibrotic mediator CTGF, the inhibitor of ECM degradation PAI-1, and collagen production, all of them regulated by Smads [7], [29], [30].
CTGF Negative_regulation (inhibitor) of PAI-1
1) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

This test has worked.

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