INT254875

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.07
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
striatum 1
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
depression 4 90.16 High High
gABA 6 86.56 High High
Dopamine 6 85.40 High High
Neurotransmitter 5 85.04 High High
Glutamate 48 84.08 Quite High
midbrain 3 79.04 Quite High
Pyramidal cell 16 76.92 Quite High
Calcium channel 2 75.84 Quite High
antagonist 2 74.56 Quite High
Inflammation 46 73.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 232 100.00 Very High Very High Very High
Disease 524 99.44 Very High Very High Very High
Toxicity 41 99.36 Very High Very High Very High
Neurodegenerative Disease 63 95.12 Very High Very High Very High
Death 63 90.32 High High
Depression 4 90.16 High High
Stress 33 88.32 High High
Convulsion 2 88.32 High High
Dementia 6 82.88 Quite High
Frailty 18 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HdhQ150/Q150 homozygous knock-in mice [12], [13] on a (CBA x C57Bl/6) F1 background were generated by intercrossing HdhQ150/Q7 heterozygous CBA/Ca and C57BL/6J congenic lines (inbred lines from Harlan Olac, Bicester, UK).
Positive_regulation (generated) of HdhQ150 associated with targeted disruption
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 0.69 Pain Relevance 0.03
Tet-on stable cell lines and quantification of induced Htt genes
Positive_regulation (induced) of Htt
2) Confidence 0.43 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
RT-PCR was used to compare endogenous wild-type Htt and Tet-induced mutant Htt (Fig. 3 D, top).
Positive_regulation (induced) of mutant Htt
3) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
Therefore, we could not determine whether a further reduction of Ku70 accelerates mutant Htt–induced neurodegeneration at the mouse level.


Spec (whether) Positive_regulation (accelerates) of mutant Htt
4) Confidence 0.41 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.07 Pain Relevance 0
Semiquantification of induced EGFP-Htt and endogenous Htt in the Tet-on stable cells was performed with 5?
Positive_regulation (induced) of EGFP-Htt
5) Confidence 0.38 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
CAG repeat expansions in the htt gene result in an increased number of glutamine residues in the huntingtin protein (polyglutamine expansion).
Positive_regulation (increased) of huntingtin
6) Confidence 0.33 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.38 Pain Relevance 0.39
Interestingly, in contrast with reduced IPSC frequency in the cortex of symptomatic animals, the frequency of inhibitory GABAA receptor-mediated synaptic events is increased in the striatum of R6/2 and other models of HD (Cepeda et al., 2004; Cummings et al., 2007).
Positive_regulation (increased) of HD in striatum
7) Confidence 0.19 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.15 Pain Relevance 0.22
In contrast, when normalized to evoked AMPA currents, postsynaptic NMDA currents were enhanced in all three pathologic HD YAC variants (Milnerwood and Raymond, 2007).
Positive_regulation (enhanced) of HD
8) Confidence 0.19 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.22 Pain Relevance 0.14
PSA suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo
Positive_regulation (accumulation) of huntingtin associated with toxicity
9) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.16 Pain Relevance 0
Inhibition of autophagy by chemical regulators, such as bafilomycin A1 and 3-methyladenine, decreases the clearance of aggregate-prone proteins such as mutant huntingtin (that causes Huntington's disease) or mutant forms of alpha-synuclein that cause familial Parkinson's disease.
Positive_regulation (causes) of mutant huntingtin associated with disease
10) Confidence 0.06 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 1.01 Pain Relevance 0
Like rapamycin, these drugs increase the clearance of aggregate-prone proteins like mutant huntingtin and have beneficial effects in fly models of HD [78–80].
Positive_regulation (increase) of mutant huntingtin associated with disease
11) Confidence 0.06 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.39 Pain Relevance 0.18

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