INT255100

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.30
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
myoblasts 6
skeletal muscle 2
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 90.12 High High
Inflammation 2 84.40 Quite High
tolerance 13 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 124 99.48 Very High Very High Very High
Toxicity 70 99.32 Very High Very High Very High
Hypopituitarism 47 96.52 Very High Very High Very High
Arrhythmia Under Development 15 96.12 Very High Very High Very High
Frailty 35 95.00 High High
Sprains And Strains 16 94.88 High High
Arrhythmias 2 Under Development 32 94.08 High High
Disease 87 93.56 High High
Myotonia 28 92.96 High High
Cv General 2 Under Development 12 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, overexpression of DMPK 3' UTR mRNA in mouse skeletal muscle also induced transcriptional activation of Nkx2-5 and its targets.
Positive_regulation (overexpression) of Gene_expression (overexpression) of DMPK in skeletal muscle
1) Confidence 0.56 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.42 Pain Relevance 0
Overexpression of a normal DMPK 3´UTR (five CUG repeats) as part of an inducible RNA transcript was reported to cause myotonia, cardiac conduction abnormalities, histopathology and RNA splicing defects in the absence of detectable nuclear inclusions.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of DMPK associated with arrhythmia under development and hypopituitarism
2) Confidence 0.56 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.46 Pain Relevance 0
As noted above, a study by Wang and colleagues demonstrates that inducible expression of 960 interrupted CUG repeats located in the DMPK 3?
Positive_regulation (inducible) of Gene_expression (expression) of DMPK
3) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.28 Pain Relevance 0
Expression of LacZ-(CUG)400 RNAs at levels equivalent to that of a DMPK mini gene encoding 300 CTG repeats does not result in aberrant RNA splicing in human myoblasts
Positive_regulation (equivalent) of Gene_expression (Expression) of DMPK mini gene in myoblasts
4) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.24 Pain Relevance 0
Expression of LacZ-(CUG)400 RNAs at levels equivalent to that of a DMPK mini gene encoding 300 CTG repeats does not result in aberrant RNA splicing in human myoblasts
Neg (not) Positive_regulation (result) of Gene_expression (Expression) of DMPK mini gene in myoblasts
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.25 Pain Relevance 0
Overexpression of a normal DMPK 3´UTR (five CUG repeats) as part of an inducible RNA transcript was reported to cause myotonia, cardiac conduction abnormalities, histopathology and RNA splicing defects in the absence of detectable nuclear inclusions.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of DMPK associated with arrhythmia under development and hypopituitarism
6) Confidence 0.40 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.46 Pain Relevance 0
What is the mechanism by which multiple copies of the normal 3’ UTR of DMPK cause DM1 phenotype?
Positive_regulation (cause) of Gene_expression (copies) of DMPK
7) Confidence 0.38 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.51 Pain Relevance 0
Consistent with these findings, expression of the mutant DMPK in C2C12 myoblasts increases stability of TNF mRNA [87].
Positive_regulation (increases) of Gene_expression (expression) of DMPK in myoblasts
8) Confidence 0.38 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.39 Pain Relevance 0.13
A requirement for general transcription factors in different tissues that express DMPK would account for the multisystemic and multisymptomatic nature of DM1.
Positive_regulation (requirement) of Gene_expression (express) of DMPK
9) Confidence 0.38 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.30 Pain Relevance 0

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