INT255146

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytoplasm (Dmpk, Hnrnph1) nucleus (Dmpk, Hnrnph1) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk) cytosol (Dmpk) mRNA processing (Hnrnph1)

Anatomy Link Frequency nucleus 2 Dmpk (Mus musculus) Hnrnph1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 3 5.00 anesthesia 2 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Infection 1 49.44 Targeted Disruption 18 5.00 Toxicity 10 5.00 Congenital Anomalies 9 5.00 Arrhythmias 2 Under Development 8 5.00 Cytomegalovirus Infection 5 5.00 Heart Disease 4 5.00 Sprains And Strains 4 5.00 Cv General 2 Under Development 4 5.00 Frailty 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus small molecules that decrease the rate of either MBNL1 or hnRNP H binding to the mutant DMPK RNA may serve to increase its transport out of the nucleus.

Negative_regulation (decrease) of DMPK Binding (binding) of hnRNP H in nucleus

1) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0 Pain Relevance 0

General Comments

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