INT255516

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.17
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) plasma membrane (GP6) molecular_function (COL5A2)
Anatomy Link Frequency
platelets 5
COL5A2 (Homo sapiens)
GP6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 45 97.76 Very High Very High Very High
antagonist 27 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 9 100.00 Very High Very High Very High
Adhesions 405 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet adhesion to collagen is a key initial step in arterial thrombosis.1 Collagen interacts directly with platelets via glycoprotein VI (GpVI), which mediates platelet activation, and integrin ?
collagen Binding (interacts) of GpVI in platelets associated with thrombosis and adhesions
1) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.29 Pain Relevance 0
Platelet adhesion to collagen is a key initial step in arterial thrombosis.1 Collagen interacts directly with platelets via glycoprotein VI (GpVI), which mediates platelet activation, and integrin ?
Collagen Binding (interacts) of glycoprotein VI in platelets associated with thrombosis and adhesions
2) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.29 Pain Relevance 0
Platelet adhesion to collagen is a key initial step in arterial thrombosis.1 Collagen interacts directly with platelets via glycoprotein VI (GpVI), which mediates platelet activation, and integrin ?
collagen Binding (interacts) of glycoprotein VI in platelets associated with thrombosis and adhesions
3) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.29 Pain Relevance 0
These data indicate that GpVI interacts with specific loci in collagen and that motifs other than OGP/GPO contribute to these binding sites.


collagen Binding (interacts) of GpVI
4) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0
Platelet adhesion to collagen is a key initial step in arterial thrombosis.1 Collagen interacts directly with platelets via glycoprotein VI (GpVI), which mediates platelet activation, and integrin ?
Collagen Binding (interacts) of GpVI in platelets associated with thrombosis and adhesions
5) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.29 Pain Relevance 0
Peptide III-30 may prove a valuable tool for modeling and understanding the GpVI-collagen interaction, and provide insights into the differences between human and murine GpVI binding to collagen.
collagen Binding (interaction) of GpVI
6) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.05
These data suggest that the particular spatial arrangement generated when collagen clusters GpVI is a significant determinant of the subsequent activation of the platelet and further support the view that the interactions of human and murine GpVI with collagen differ significantly.
collagen Binding (interactions) of GpVI in platelet
7) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.06
Peptide III-30 may prove a valuable tool for modeling and understanding the GpVI-collagen interaction, and provide insights into the differences between human and murine GpVI binding to collagen.
collagen Binding (interaction) of GpVI
8) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.05
Peptide III-30 may prove a valuable tool for modeling and understanding the GpVI-collagen interaction, and provide insights into the differences between human and murine GpVI binding to collagen.
collagen Binding (binding) of GpVI
9) Confidence 0.01 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.05

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