INT255657

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 2
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 13 69.72 Quite High
Glutamate 34 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 49 90.48 High High
Disease 16 87.36 High High
Glaucoma 56 86.32 High High
Alzheimer's Dementia 9 80.16 Quite High
Toxicity 3 73.76 Quite High
Ocular Hypertension 15 66.56 Quite High
Optic Disorders 1 39.72 Quite Low
Targeted Disruption 2 21.24 Low Low
Death 17 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-Secretase, a membrane-anchored aspartic protease, is responsible for the initial step of APP cleavage in the amyloidogenic pathway leading to the generation of A?
Negative_regulation (step) of Protein_catabolism (cleavage) of APP in cleavage
1) Confidence 0.20 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.07 Pain Relevance 0.03

General Comments

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