INT255788

Context Info Confidence 0.01 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.39 Pain Relevance 0.19

endoplasmic reticulum (Aadac)

Aadac (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 94 99.54 Intracerebroventricular 1 53.20 cytokine 13 51.56 Hippocampus 5 46.64 ischemia 2 29.48 cINOD 17 5.00 Nicotine 13 5.00 Inflammatory response 9 5.00 Somatostatin 9 5.00 agonist 8 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 105 99.54 Lifespan 2 95.28 Disease 168 92.64 Aging 8 89.52 Alzheimer's Dementia 18 85.72 Drug Induced Neurotoxicity 3 84.40 Pathologic Processes 1 84.28 Toxicity 4 76.96 Targeted Disruption 14 48.56 Brain Injury 1 42.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, resveratrol binds to and activates the deacetylase activity of several sirtuin members, including the mammalian ortholog, SIRT1, by lowering the Michaelis constants of these enzymes [37].

Positive_regulation (activates) of deacetylase

1) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.66 Pain Relevance 0.03

Resveratrol has anti-inflammatory properties due to its activation of SIRT-1, a class III histone deacetylase; activation of SIRT-1 by resveratrol inhibited NF-?

Positive_regulation (activation) of deacetylase associated with inflammation

2) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.73 Pain Relevance 0.16

General Comments

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