INT25582

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Context Info
Confidence 0.03
First Reported 1989
Last Reported 2006
Negated 0
Speculated 1
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 0.40
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
lymphocyte 1
brain 1
peritoneal macrophages 1
Mtr (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
Opioid 1 100.00 Very High Very High Very High
cytokine 3 92.28 High High
alcohol 2 89.48 High High
Physical dependence 1 74.36 Quite High
narcan 1 72.72 Quite High
opioid receptor 1 68.56 Quite High
withdrawal 2 62.40 Quite High
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 1 97.48 Very High Very High Very High
Necrosis 1 97.24 Very High Very High Very High
Drug Dependence 1 74.36 Quite High
Hyperplasia 1 70.28 Quite High
Alcohol Addiction 1 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methionine-enkephalin alteration of mitogenic and mixed lymphocyte culture responses in zinc-deficient mice.
Regulation (alteration) of Methionine-enkephalin in lymphocyte associated with enkephalin
1) Confidence 0.03 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 2532855 Disease Relevance 0.07 Pain Relevance 0.27
Effects of chronic ethanol administration on brain interstitial fluid levels of Methionine-enkephalin as measured by microdialysis in vivo.
Regulation (Effects) of Methionine-enkephalin in brain associated with enkephalin
2) Confidence 0.02 Published 2006 Journal Peptides Section Title Doc Link 16672169 Disease Relevance 0.14 Pain Relevance 0.74
In the present study, we have examined the effect of opioid peptide methionine enkephalin (MENK) on production of factors with interleukin-1 (IL-1) and tumor necrosis factor (TNF) activity by mouse peritoneal macrophages and assessed whether modification in the production of those cytokines could be related to alteration of phagocytosis by MENK.
Spec (examined) Regulation (effect) of methionine enkephalin in peritoneal macrophages associated with necrosis, cancer, enkephalin, opioid and cytokine
3) Confidence 0.01 Published 1994 Journal Immunol. Lett. Section Abstract Doc Link 7927513 Disease Relevance 0.19 Pain Relevance 0.75

General Comments

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