INT256079

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) extracellular region (Serpina3k) Golgi apparatus (Fig4)
endoplasmic reticulum (Fig4)
Serpina3k (Rattus norvegicus)
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 26 100.00 Very High Very High Very High
Death 24 50.00 Quite Low
Necrosis 15 33.52 Quite Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Nerve Degeneration 4 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 3 5.00 Very Low Very Low Very Low
Retina Disease 3 5.00 Very Low Very Low Very Low
Retinoblastoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 15 min, the SERPINA3K treatment prevented the phosphorylation of PLC induced by H2O2 (60% reduction), but did not inhibit the phosphorylation of the ERK or PI3K/AKT kinases, suggesting that SERPINA3K specifically blocks the activation of PLC under oxidative stress (Fig. 6D, F).


SERPINA3K Negative_regulation (blocks) of Fig associated with stress
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605247 Disease Relevance 0.16 Pain Relevance 0

General Comments

This test has worked.

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