INT256702

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0

endoplasmic reticulum (Wfs1, Tmed4) signal transduction (Tmed4) transport (Tmed4) neurological system process (Wfs1) signal transducer activity (Tmed4)

Wfs1 (Mus musculus) Tmed4 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 4 5.00 depression 3 5.00 Migraine 1 5.00 anticonvulsant 1 5.00 Neurotransmitter 1 5.00 GABAergic 1 5.00

Disease Link Frequency Relevance Heat Stress 21 100.00 Manic Depressive Disorder 19 81.88 Oxidative Phosphorylation Disease 3 5.00 Depression 3 5.00 Convulsion 2 5.00 Optic Atrophy 1 5.00 Diabetes Mellitus 1 5.00 Epilepsy 1 5.00 Diabetes Insipidus 1 5.00 Headache 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, WFS1 forms a complex with GRP94, an ER stress-response protein, in which valproate dose-dependently enhances its dissociation from GRP94.

WFS1 Binding (complex) of ER stress-response protein associated with stress

1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2607540 Disease Relevance 0.61 Pain Relevance 0

General Comments

This test has worked.