INT256915

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccne2) cell cycle (Ccne2) cell division (Ccne2)
Ccne2 (Mus musculus)
Pain Link Frequency Relevance Heat
IPN 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 98.96 Very High Very High Very High
Cancer 54 90.24 High High
Adenocarcinoma 2 88.60 High High
Colon Cancer 2 87.16 High High
Skin Cancer 10 72.84 Quite High
Leukemia 2 72.28 Quite High
Lymphatic System Cancer 2 71.88 Quite High
Targeted Disruption 72 64.12 Quite High
Hyperplasia 10 55.04 Quite High
Papillomavirus Infection 28 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observed up-regulation in E2F-responsive genes belonging to the MCM family, involved in DNA replication [41], and in cyclin E, involved in the G1-S transition [42].
Regulation (regulation) of cyclin E
1) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.54 Pain Relevance 0
In summary, we identified important genes that are altered at the transcriptional level by E6 in our model, in particular the uncoupling of cell cycle regulation (cdc2, cyclin B, cdk2 and cyclin E), down-regulation of pro-apoptotic genes (Fas) and up-regulation of anti-apoptotic genes (Birc5).
Regulation (regulation) of cyclin E associated with apoptosis
2) Confidence 0.20 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.44 Pain Relevance 0

General Comments

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