INT256920

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf3) DNA binding (Irf3) cytoplasm (Irf3)
Irf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 244 89.40 High High
depression 8 69.52 Quite High
Multiple sclerosis 6 61.68 Quite High
cytokine 2 55.12 Quite High
Central nervous system 2 40.88 Quite Low
Analgesic 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 29 97.48 Very High Very High Very High
Influenza Virus Infection 4 95.24 Very High Very High Very High
Targeted Disruption 36 94.80 High High
Viral Infection 3 88.16 High High
Depression 8 69.52 Quite High
Skin Cancer 5 67.16 Quite High
Autoimmune Disease 2 64.24 Quite High
Papillomavirus Infection 14 63.28 Quite High
Demyelinating Disease 6 61.68 Quite High
Cervical Cancer 9 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B and IRF-3 binding [3], [4].
IRF-3 Binding (binding) of
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.37 Pain Relevance 0.17
Ifit-3 is involved in the activation of cytosolic IRF-3 and NF-?
IRF-3 Binding (cytosolic) of
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.07 Pain Relevance 0.67
It has been reported that E6 from HPV16 binds to interferon regulatory factor-3 interfering with its activity [57], that could explain why we observed down-regulation of many Interferon-inducible genes such as myxovirus (influenza virus) resistance 1 (Mx1), Oas2 and Stat-1.
interferon regulatory factor-3 Binding (interfering) of associated with influenza virus infection
3) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.93 Pain Relevance 0

General Comments

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