INT257325

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Cybb (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 4 25.76 Inflammation 8 5.00 anesthesia 4 5.00 antagonist 4 5.00 ketamine 2 5.00

Disease Link Frequency Relevance Heat Hypertension 28 50.00 Cardiovascular Disorder Under Development 8 50.00 Body Weight 2 43.96 Coronary Heart Disease 6 27.68 Fibrosis 6 25.76 Stress 16 11.68 Hypertrophy 10 5.00 INFLAMMATION 8 5.00 Injury 6 5.00 Hyperplasia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Spironolactone significantly decreased p47phox and gp91phox mRNA expression.

Negative_regulation (decreased) of Transcription (expression) of gp91phox

1) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0

Spironolactone and losartan significantly decreased p47phox, gp91phox, and p22phox mRNA expression.

Negative_regulation (decreased) of Transcription (expression) of gp91phox

2) Confidence 0.01 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.