INT25738

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.99
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrng)
Anatomy Link Frequency
muscle 1
cerebral cortex 1
cortex 1
Chrng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
pulpitis 2 99.82 Very High Very High Very High
opioid receptor 17 99.52 Very High Very High Very High
agonist 7 98.78 Very High Very High Very High
cerebral cortex 1 95.92 Very High Very High Very High
Potency 2 91.40 High High
medulla 7 91.16 High High
midbrain 3 88.12 High High
repetitive firing 1 87.76 High High
depression 26 85.60 High High
antagonist 7 85.24 High High
Disease Link Frequency Relevance Heat
Pulpitis 2 99.82 Very High Very High Very High
Bordatella Infection 2 98.88 Very High Very High Very High
Depression 23 85.60 High High
Urological Neuroanatomy 1 78.84 Quite High
INFLAMMATION 4 75.00 Quite High
Drug Dependence 2 67.56 Quite High
Poisoning 2 66.12 Quite High
Neuroleptic Malignant Syndrome 4 56.44 Quite High
Headache 1 25.00 Low Low
Arthralgia 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It thus appears that mAChR regulation in the rat cerebral cortex is linked to changes in active K+-channel currents: activation of the K+-channel by depolarization-induced changes in K+ current or by agonist stimulation leading to changes in the selective K+ currents stimulate mAChR down-regulation; blockage of the K+-channels prevents this down-regulation.
Positive_regulation (stimulate) of mAChR in cerebral cortex associated with agonist and cerebral cortex
1) Confidence 0.43 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2538705 Disease Relevance 0.11 Pain Relevance 0.24
In contrast, ethanol caused only a small (1.3-fold) increase in the abundance of hm4 mAChR mRNA and did not change levels of G alpha i2 and G alpha s mRNAs.
Positive_regulation (increase) of mAChR
2) Confidence 0.04 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226869 Disease Relevance 0.08 Pain Relevance 0.17
Pertussis toxin pretreatment did not prevent the ethanol-induced increase in alpha 2AR, mAChR, and delta-opioid receptor expression.
Positive_regulation (increase) of mAChR associated with bordatella infection and opioid receptor
3) Confidence 0.03 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8226869 Disease Relevance 0.23 Pain Relevance 0.35
Pulpitis changed mAChR conformation, increasing its coupling efficiency to transducing molecules that in turn activate iNOS.
Positive_regulation (increasing) of mAChR associated with pulpitis
4) Confidence 0.02 Published 2009 Journal J Endod Section Abstract Doc Link 19345799 Disease Relevance 0.29 Pain Relevance 0.34
Treatment with PB, DEET, and permethrin alone caused a significant increase in ligand binding for m2 muscarinic acetylcholine receptor (mAChR) in the cortex.
Positive_regulation (increase) of mAChR in cortex
5) Confidence 0.02 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11248143 Disease Relevance 0 Pain Relevance 0.35
These results suggest that carbachol-activation of M(1) and M(3) mAChR increased PGE(2) release associated with an increased expression of cox-1 and NO-cGMP production.
Positive_regulation (increased) of mAChR
6) Confidence 0.01 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814109 Disease Relevance 0.08 Pain Relevance 0.08
This development change is consistent with the observation in adult rat that mAChR activation suppresses inspiratory-related activity of the genioglossus muscle [36].


Positive_regulation (activation) of mAChR in muscle
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.20 Pain Relevance 0.17

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