INT257559

Context Info Confidence 0.69 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 1.43 Pain Relevance 0.12

AIC (Homo sapiens)

Pain Link Frequency Relevance Heat Autonomic response 28 89.08 insula 16 28.32 imagery 6 24.60 Somatosensory cortex 10 13.80 depression 11 5.00 Central nervous system 8 5.00 Inflammatory marker 5 5.00 primary somatosensory cortex 4 5.00 Pain 3 5.00 addiction 3 5.00

Disease Link Frequency Relevance Heat Epilepsy 2 98.10 Alagille Syndrome 38 98.06 Body Weight 10 91.12 Congenital Anomalies 41 87.40 Cognitive Disorder 21 72.72 Fatigue 26 62.48 Osteoporosis 9 50.00 Chronic Fatigue Syndrome 49 47.28 Urological Neuroanatomy 6 5.92 Obesity 23 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In any case, similarly as in the pMFC (Ullsperger and von Cramon 2001; Garavan et al. 2003; Rushworth et al. 2004; Nachev et al. 2005) there seems to be a functional gradient in the localization of activity within the AIC.

Localization (localization) of AIC

1) Confidence 0.69 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0 Pain Relevance 0

Also invasive electrophysiology (e.g., in the context of epilepsy diagnostics with depth electrodes) could provide valuable information.Is there any functional subregionalization of the AIC?

Localization (subregionalization) of AIC associated with epilepsy

2) Confidence 0.64 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.17 Pain Relevance 0.12

We utilized AIC3 for the Wichita study and also utilize it here.

Localization (utilized) of AIC3

3) Confidence 0.06 Published 2009 Journal Popul Health Metr Section Body Doc Link PMC2761845 Disease Relevance 0.11 Pain Relevance 0

In the simplest model comprising AHD and WOD only (Model 1), the regression coefficients were 1.329 and 1.614, respectively, and the AIC was calculated to be 96.28.

Localization (calculated) of AIC associated with alagille syndrome

4) Confidence 0.05 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2613887 Disease Relevance 1.14 Pain Relevance 0

General Comments

This test has worked.