INT257931

Context Info Confidence 0.26 First Reported 2008 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 7 Total Number 8 Disease Relevance 5.12 Pain Relevance 0.30

Anatomy Link Frequency B cells 1 striatum 1 DCs 1 H2 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 16 99.98 imagery 49 89.76 dopaminergic neurodegeneration 4 89.48 Potency 1 87.76 Deep tissue 2 79.76 cytokine 25 79.68 Serotonin 4 45.56 Dopamine 46 44.04 Analgesic 1 37.16 antagonist 18 31.08

Disease Link Frequency Relevance Heat Parkinson's Disease 357 99.72 Sprains And Strains 165 97.16 Movement Disorders 8 94.24 Disease 292 93.40 Acute Disease 1 93.08 Drug Induced Neurotoxicity 28 91.24 Stress 88 89.12 Syndrome 8 87.40 Targeted Disruption 20 85.56 Injury 8 74.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We could detect the change in H2 in the striatum during the inhalation of H2 (Figure S2).

Regulation (change) of H2 in striatum

1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0 Pain Relevance 0

Though the effects of H2 water on behavioral response were not tested in older mice in the current study, our results raised a possibility that H2 water may reduce the movement disorder in PD patients.

Regulation (effects) of H2 associated with movement disorders and disease

2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.95 Pain Relevance 0.04

The effect of H2 water in chronic MPTP infusion model

Regulation (effect) of H2 associated with parkinson's disease

3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.34 Pain Relevance 0

H2 values were indeed significantly higher than in human populations, in particular for SBP, HR and ECG intervals (see for instance [36], [37] and [38]), where H2 estimates typically vary around 0.6 in twin studies and around 0.25 in nuclear families.

Regulation (values) of H2

4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722085 Disease Relevance 0.32 Pain Relevance 0

Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.

Regulation (evaluated) of MHC II in B cells

5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13

Without MPTP administration, H2/Mg water had no effect on the number of TH-positive cells (195±8; non-H2/Mg water, 194±4; H2/Mg water, Figure 3A, 3C).

Neg (no) Regulation (effect) of H2 associated with parkinson's disease

6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.83 Pain Relevance 0

Not only do innate immune cells down-regulate MHC II, but decreased numbers of Langerhans cells (LCs; the DCs of the skin) have been observed consistently in both elderly humans and old mice.

Regulation (regulate) of MHC II in DCs

7) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.05 Pain Relevance 0.04

It also has a partial, weak agonist effect on H1 and H2 receptors [61, 162].

Spec (partial) Regulation (effect) of H2 associated with agonist

8) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.54 Pain Relevance 0.09

General Comments

This test has worked.