INT258528

Context Info Confidence 0.07 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.60 Pain Relevance 0

extracellular region (NOTCH1, DLL1) plasma membrane (NOTCH1, DLL1) cell differentiation (DLL1) nucleoplasm (NOTCH1) Golgi apparatus (NOTCH1) embryo development (NOTCH1)

Anatomy Link Frequency Notch 2 NOTCH1 (Homo sapiens) DLL1 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 5 5.00 metalloproteinase 4 5.00 Sicca syndrome 1 5.00 Somatostatin 1 5.00 Glutamate 1 5.00 Pain 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 249 91.68 Manic Depressive Disorder 2 83.64 Cancer 88 75.84 Non-small-cell Lung Cancer 3 58.00 Pancreatic Cancer 1 54.24 Renal Cancer 2 54.16 Colon Cancer 1 52.72 Cervical Cancer 1 49.76 Lymphatic System Cancer 1 45.68 Apoptosis 5 41.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).

Notch Binding (ligands) of DLL-1 in Notch

1) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.73 Pain Relevance 0

Binding of any one of the Notch ligands (e.g., DLL-1 or JAG-1) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).

Notch Binding (ligands) of DLL-1 in Notch

2) Confidence 0.06 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.87 Pain Relevance 0

General Comments

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