INT258529

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (JAG1, NOTCH1) plasma membrane (JAG1, NOTCH1) nucleoplasm (NOTCH1)
Golgi apparatus (NOTCH1) embryo development (NOTCH1) cytoplasm (NOTCH1)
Anatomy Link Frequency
Notch 3
JAG1 (Homo sapiens)
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 9 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Sicca syndrome 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 410 91.68 High High
Manic Depressive Disorder 3 83.64 Quite High
Cancer 142 75.84 Quite High
Non-small-cell Lung Cancer 4 58.72 Quite High
Pancreatic Cancer 2 55.76 Quite High
Renal Cancer 3 54.88 Quite High
Colon Cancer 2 54.24 Quite High
Cervical Cancer 2 51.28 Quite High
Lymphatic System Cancer 2 47.20 Quite Low
Apoptosis 8 42.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
JAG-1 Binding (ligands) of Notch in Notch
1) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.79 Pain Relevance 0
Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
Jagged1 Binding (ligands) of Notch in Notch
2) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.78 Pain Relevance 0
Binding of any one of the Notch ligands (e.g., DLL-1 or JAG-1) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
JAG-1 Binding (ligands) of Notch in Notch
3) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.88 Pain Relevance 0

General Comments

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