INT258590

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.17
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA3) plasma membrane (ADORA3) signal transducer activity (ADORA3)
Anatomy Link Frequency
CPA 1
ovary 1
ADORA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 610 100.00 Very High Very High Very High
Cannabinoid receptor 9 99.72 Very High Very High Very High
Potency 98 96.56 Very High Very High Very High
adenocard 115 94.92 High High
antagonist 133 94.48 High High
Neuropathic pain 7 61.44 Quite High
ischemia 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 61.44 Quite High
Chronic Renal Failure 7 50.88 Quite High
Hypercalcemia 7 48.52 Quite Low
Disease 7 25.12 Quite Low
Neuroblastoma 3 8.24 Low Low
Cv Unclassified Under Development 7 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Reprotox - General 2 7 5.00 Very Low Very Low Very Low
Pituitary Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chinese hamster ovary (CHO) cells stably expressing A1 or A3 AR were maintained at 37°C with 5% CO2 in a 1:1 mixture of Dulbecco's modified Eagle's medium (DMEM) and Ham's F12 medium, supplemented with 10% fetal bovine serum (FBS), 100 units/ml penicillin, 100 ?
Gene_expression (expressing) of A3 AR in ovary
1) Confidence 0.36 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.26
In this study, we extended our previous observations by studying the nature of the potentially flexible modulation by LUF6000 of the agonists with a selection of A3 AR agonists having a distribution of Emax values in A3 AR-expressing CHO cells using a [35S]GTP?
Gene_expression (expressing) of A3 AR associated with agonist
2) Confidence 0.36 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0.06 Pain Relevance 0.52
M, did not show any effect on the basal level of A3 AR activation in this [35S]GTP?
Gene_expression (activation) of A3 AR
3) Confidence 0.32 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.42
Unlike its effect on the A3 AR, LUF6000 did not affect the Emax of two high-efficacy agonists CPA and CCPA or a low efficacy agonist MRS541 to activate the A1 AR (Figure 4).


Gene_expression (effect) of A3 AR in CPA associated with agonist
4) Confidence 0.32 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.32
In this study, we extended our previous observations by studying the nature of the potentially flexible modulation by LUF6000 of the agonists with a selection of A3 AR agonists having a distribution of Emax values in A3 AR-expressing CHO cells using a [35S]GTP?
Gene_expression (agonists) of A3 AR associated with agonist
5) Confidence 0.32 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0.11 Pain Relevance 0.51
Here we studied the modulation by LUF6000 of the maximum effect (Emax) of structurally diverse agonists at the A3 AR stably expressed in CHO cells.


Gene_expression (expressed) of A3 AR associated with agonist
6) Confidence 0.28 Published 2008 Journal BMC Pharmacol Section Abstract Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.43
The preparation of membranes from CHO cells stably expressing human A1 or A3 AR was as previously described [18]. [35S]GTP?
Gene_expression (expressing) of A3 AR
7) Confidence 0.28 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.14
We can confirm that as reported in the literature BV2 cells express Adora3 [59], Cnr2 [33,58], Mtnr1a [60], Galr2 [61], Ccr5, Cxcr3 [62] and Rgs2, 10, 12 [27,28,63].
Gene_expression (express) of Adora3 associated with cannabinoid receptor
8) Confidence 0.09 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0.09

General Comments

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