INT258687

Context Info Confidence 0.42 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.28 Pain Relevance 0.29

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1) cytoplasm (Gpd1)

Gpd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat monoamine 6 84.32 Neurotransmitter 12 83.20 Dopamine 8 74.24 Serotonin 4 73.20 Potency 2 64.04 Neurobehavioral 2 20.88 hyperexcitability 8 9.72 bDMF 10 5.00 member 8 2 5.00 sodium channel 2 5.00

Disease Link Frequency Relevance Heat Stress 2 96.44 Toxicity 2 75.24 Drug Induced Neurotoxicity 6 59.76 Urological Neuroanatomy 16 51.84 Repression 4 42.80 Poisoning 8 18.88 Neuroblastoma 4 5.00 Osteogenic Sarcomas 4 5.00 Shock 4 5.00 Hypoxia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The potential impact of increased Gpd1 and Fkbp51 expression on the health and function of affected glia, to date, is unclear.

Regulation (impact) of Gpd1

1) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0.26

Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.

Regulation (changes) of Gpd3

2) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03

General Comments

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