INT258695

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.13
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Camk1g) plasma membrane (Camk1g) cytoplasm (Camk1g)
Anatomy Link Frequency
neuronal 2
neurons 2
Camk1g (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurobehavioral 2 72.28 Quite High
Neurotransmitter 12 65.08 Quite High
monoamine 6 64.40 Quite High
Dopamine 8 58.52 Quite High
Serotonin 4 48.52 Quite Low
bDMF 10 5.00 Very Low Very Low Very Low
hyperexcitability 8 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Nav1.2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 8 73.16 Quite High
Repression 4 61.12 Quite High
Urological Neuroanatomy 16 50.00 Quite Low
Stress 2 27.60 Quite Low
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, increased expression of c-fos, Egr1 and Camk1g in the present study are most likely regulated by pyrethroid-induced changes in the neuronal firing patterns of cortical neurons.
Regulation (regulated) of Gene_expression (expression) of Camk1g in neurons
1) Confidence 0.41 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.13 Pain Relevance 0.16
These observations support that pyrethroid-mediated changes in neuronal firing rates could mediate changes in the expression of Camk1g, which may in turn lead to changes in neuronal morphology (see below), especially during development.
Regulation (changes) of Gene_expression (expression) of Camk1g in neuronal
2) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0

General Comments

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