INT259061

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.23
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
A549 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 63.36 Quite High
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 562 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 3 99.50 Very High Very High Very High
Death 28 98.44 Very High Very High Very High
Apoptosis 152 93.76 High High
Chromosome Aberrations 1 82.24 Quite High
Colon Cancer 23 80.96 Quite High
Genomic Instability 1 80.76 Quite High
Cervical Cancer 107 73.76 Quite High
Infection 65 68.00 Quite High
Skin Cancer 8 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results obtained with human nonsmall cell lung cancer A549 cells suggest that downregulation of Bcl-xL, COX-2, and MAP kinase pathway and up-regulation of p53, Akt, and NF?
Negative_regulation (downregulation) of Regulation (regulation) of p53 in A549 associated with non-small-cell lung cancer
1) Confidence 0.10 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.08 Pain Relevance 0.03
In targeting p53, the high-risk HPV E6 proteins inhibit DNA damage and oncogene-mediated cell death signals.
Negative_regulation (inhibit) of Regulation (targeting) of p53 associated with papillomavirus infection and death
2) Confidence 0.04 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 1.15 Pain Relevance 0

General Comments

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