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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2008
Negated 3
Speculated 1
Reported most in Body
Documents 1
Total Number 60
Disease Relevance 71.49
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transcription factor binding (LMO4)
Anatomy Link Frequency
fibroblasts 4
dorsal 2
epithelial cell 2
somites 2
cranial neural crest cells 2
LMO4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 60 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 2220 99.96 Very High Very High Very High
Carcinoma 1320 99.86 Very High Very High Very High
Ductal Carcinoma 1080 99.86 Very High Very High Very High
Breast Cancer 600 99.80 Very High Very High Very High
Adenoma 900 99.60 Very High Very High Very High
Cleidocranial Dysplasia 180 99.52 Very High Very High Very High
Malignant Neoplastic Disease 660 99.44 Very High Very High Very High
Cancer 2280 99.26 Very High Very High Very High
Metastasis 60 98.44 Very High Very High Very High
Mouth Cancer 60 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kenny et al [13] reported the isolation and characterization of LMO4, a novel LIM-only gene that is highly expressed in the T-lymphocyte lineage, cranial neural crest cells, somites, dorsal limb bud mesenchyme, motor neurons and Schwann cell progenitors.
Gene_expression (expressed) of LMO4 in dorsal
1) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.27 Pain Relevance 0
As shown in Figure 5, IDC cells expressed significantly higher levels of LMO4 than did normal ductal epithelial or PanIN-1B cells (p < 0.0001 for both) or PanIN-2 cells (p = 0.014).
Gene_expression (expressed) of LMO4 associated with ductal carcinoma
2) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.80 Pain Relevance 0
To avoid the influence of LMO4-expressing non-ductal cells contained in bulk tissues, we microdissected target cells, such as IDCs, PanINs, IPMNs and non-neoplastic ductal cells, and measured LMO4 expression in the microdissected cells.
Gene_expression (expression) of LMO4
3) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.27 Pain Relevance 0
Microdissection-based quantitative analysis of LMO4 expression in IDC, PanIN-2, PanIN-1B and normal ductal cells
Gene_expression (expression) of LMO4 associated with ductal carcinoma
4) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.39 Pain Relevance 0.06
Quantitative analyses of LMO4 expression in bulk pancreatic tissues
Gene_expression (expression) of LMO4
5) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.21 Pain Relevance 0.09
Bulk tissue analysis showed that pancreatic cancer tissues expressed higher levels of LMO4 than non-neoplastic and non-malignant IPMN tissues; however, the difference in LMO4 expression between non-neoplastic tissues and non-malignant IPMN was not significant.
Gene_expression (expression) of LMO4 associated with malignant neoplastic disease, cancer and pancreatic cancer
6) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.26 Pain Relevance 0
We found that the LMO4 expression in IDC cells was significantly higher than those in PanIN-1B, PanIN-2, and normal ductal cells; however, the PanIN-2 sample number was small.
Gene_expression (expression) of LMO4 associated with ductal carcinoma
7) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.49 Pain Relevance 0
To investigate the correlation of LMO4 expression with the IPMA-IPMC pathway, we microdissected IPMC cells from 5 invasive lesions and 3 non-invasive lesions (CIS), IPMB cells from 15 lesions, IPMA cells from 13 lesions and normal ductal epithelial cells from 6 ducts.
Gene_expression (expression) of LMO4 in ducts associated with adenoma and carcinoma
8) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.27 Pain Relevance 0
Taken together, these data suggested that LMO4 expression is up-regulated in pancreatic cancer but not in low-grade intraductal precursors in both the PanIN-IDC and IPMA-IPMC pathways.
Gene_expression (expression) of LMO4 associated with adenoma, ductal carcinoma, pancreatic cancer and carcinoma
9) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.53 Pain Relevance 0
We next examined whether LMO4 expression is related to the origin of these cancer cell lines, but found no correlation between LMO4 expression and site of origin, such as primary or metastatic tumors (Figure 3).


Gene_expression (expression) of LMO4 associated with cancer and metastasis
10) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.03 Pain Relevance 0.08
Kenny et al [13] reported the isolation and characterization of LMO4, a novel LIM-only gene that is highly expressed in the T-lymphocyte lineage, cranial neural crest cells, somites, dorsal limb bud mesenchyme, motor neurons and Schwann cell progenitors.
Gene_expression (expressed) of LIM-only in dorsal
11) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.26 Pain Relevance 0
As shown in Figure 4, LMO4 expression was highest in the pancreatic cancer tissues with a mean of 0.24 (95% confidence interval [CI], 0.16 – 0.32), whereas the LMO4 expression levels were 0.03 (95% CI, 0.02 – 0.04) in non-neoplastic tissues and 0.08 (95% CI, 0.04 – 0.12) in non-malignant IPMN tissues.
Gene_expression (expression) of LMO4 associated with malignant neoplastic disease, cancer and pancreatic cancer
12) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.48 Pain Relevance 0.10
In 2005, Sum and colleagues reported that LMO4 mRNA was overexpressed in 5 of 10 human breast cancer cell lines; in situ hybridization analysis of 177 primary invasive breast carcinomas revealed overexpression of LMO4 in 56% of the specimens [20].
Gene_expression (overexpression) of LMO4 associated with breast cancer
13) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.12 Pain Relevance 0
By contrast, we could not detect any differences in LMO4 expression among PanIN-1B, PanIN-2 and normal ductal cells, or among IPMA, IPMB, and normal ductal cells.
Gene_expression (expression) of LMO4 associated with adenoma
14) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.44 Pain Relevance 0
Although the mean LMO4 expression in IPMB cells (0.98; 95% CI, 0.69 – 1.27) was higher than that in IPMA (0.60; 95% CI, 0.47 – 0.73) or normal ductal cells (0.65; 95% CI, 0.34 – 0.95), the differences in LMO4 expression were not significant.
Gene_expression (expression) of LMO4 associated with adenoma
15) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.30 Pain Relevance 0
Quantitative analysis of LMO4 expression in 14 pancreatic cancer cell lines, a non-neoplastic ductal epithelial cell line and six primary cultures of pancreatic fibroblasts
Gene_expression (expression) of LMO4 in epithelial cell associated with pancreatic cancer
16) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.69 Pain Relevance 0
These data suggested that LMO4 is overexpressed in pancreatic cancer, especially in the invasive step of cancer, but not in the early stage of pancreatic carcinogenesis.


Neg (not) Gene_expression (overexpressed) of LMO4 associated with cancer and pancreatic cancer
17) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.07 Pain Relevance 0
The mean LMO4 expression level was 2.19 (95% CI, 1.43 – 2.94) in IDC cells, 0.32 (95% CI, 0.18 – 0.45) in PanIN-2 cells, 0.41 (95% CI, 0.27 – 0.54) in PanIN-1B cells and 0.45 (95% CI, 0.30 – 0.60) in normal ductal epithelial cells.
Gene_expression (expression) of LMO4 in epithelial cells associated with ductal carcinoma
18) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.83 Pain Relevance 0
It has also been reported that expression of LMO4 is up-regulated at the invasive front of oral cancer, suggesting a role in cancer cell invasion [21].
Gene_expression (expression) of LMO4 associated with cancer and mouth cancer
19) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.25 Pain Relevance 0
In the present study, we performed quantitative real-time RT-PCR to measure LMO4 expression during pancreatic carcinogenesis through the PanIN-IDC and IPMA-IPMC pathways.
Gene_expression (expression) of LMO4 associated with adenoma, ductal carcinoma and carcinoma
20) Confidence 0.78 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.09 Pain Relevance 0

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