INT25965

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.00
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pxk) nucleus (Pxk) molecular_function (Pxk)
cellular_component (Pxk) biological_process (Pxk) cytoplasm (Pxk)
Anatomy Link Frequency
trigeminal ganglion 3
neurons 1
skeletal muscle 1
ROLE 1
Pxk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
complementary and alternative medicine 144 99.96 Very High Very High Very High
Multiple sclerosis 185 95.88 Very High Very High Very High
tetrodotoxin 5 88.60 High High
Norepinephrine uptake inhibitor 1 73.68 Quite High
Desipramine 2 71.12 Quite High
Migraine 8 50.00 Quite Low
Glutamate receptor 6 28.84 Quite Low
nMDA receptor 6 19.76 Low Low
Neurotransmitter 4 18.24 Low Low
Glutamate 2 16.88 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 330 96.96 Very High Very High Very High
Demyelinating Disease 190 95.88 Very High Very High Very High
Death 62 85.80 High High
Headache 9 78.60 Quite High
Injury 6 78.32 Quite High
Necrosis 16 72.92 Quite High
Hypoxia 12 69.92 Quite High
Neurodegenerative Disease 28 64.36 Quite High
Pressure And Volume Under Development 16 63.88 Quite High
Parkinson's Disease 2 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The mRNA and protein expression levels and activity of P-type Na+ -K+ -ATPase in the trigeminal ganglion and trigeminocervical complex of the model group were 0.72 +/- 0.05, 0.59 +/- 0.05, and 5.21 +/- 0.51 respectively, and the mRNA and protein expression levels and activity of P-type Na+ -K+ -ATPase in the cortex of frontal lobe of the model group were 0.70 +/- 0.05, 0.60 +/- 0.05, and 3.61 +/- 0.49 respectively, all significantly lower than those of the control group (0.83 +/- 0.10, 0.67 +/- 0.06, 6.53 +/- 0.73, 0.81 +/- 0.08, 0.71 +/- 0.09, and 6.61 +/- 0.73 respectively, all P < 0.05).
Gene_expression (expression) of P-type Na+ -K+ -ATPase in trigeminal ganglion
1) Confidence 0.78 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18956709 Disease Relevance 0.07 Pain Relevance 0
RT-PCR and Western-blotting were used to detect the mRNA and protein expression of P-type Na+ -K+ -ATPase.
Gene_expression (expression) of P-type Na+ -K+ -ATPase
2) Confidence 0.78 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18956709 Disease Relevance 0.08 Pain Relevance 0
We conclude that alterations in the level in intracellular Na ions play the major role in regulation of Na-K pump synthesis in cultured mammalian skeletal muscle.
Gene_expression (synthesis) of Na-K in skeletal muscle
3) Confidence 0.77 Published 1989 Journal J. Cell. Physiol. Section Abstract Doc Link 2544613 Disease Relevance 0 Pain Relevance 0.23
RESULTS: The mRNA and protein expression levels and activity of P-type Na+ -K+ -ATPase in the trigeminal ganglion and trigeminocervical complex of the model group were 0.72 +/- 0.05, 0.59 +/- 0.05, and 5.21 +/- 0.51 respectively, and the mRNA and protein expression levels and activity of P-type Na+ -K+ -ATPase in the cortex of frontal lobe of the model group were 0.70 +/- 0.05, 0.60 +/- 0.05, and 3.61 +/- 0.49 respectively, all significantly lower than those of the control group (0.83 +/- 0.10, 0.67 +/- 0.06, 6.53 +/- 0.73, 0.81 +/- 0.08, 0.71 +/- 0.09, and 6.61 +/- 0.73 respectively, all P < 0.05).
Gene_expression (expression) of P-type Na+ -K+ -ATPase in trigeminal ganglion
4) Confidence 0.68 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18956709 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The mRNA and protein expression levels and activity of P-type Na+ -K+ -ATPase in the trigeminal ganglion and trigeminocervical complex of the model group were 0.72 +/- 0.05, 0.59 +/- 0.05, and 5.21 +/- 0.51 respectively, and the mRNA and protein expression levels and activity of P-type Na+ -K+ -ATPase in the cortex of frontal lobe of the model group were 0.70 +/- 0.05, 0.60 +/- 0.05, and 3.61 +/- 0.49 respectively, all significantly lower than those of the control group (0.83 +/- 0.10, 0.67 +/- 0.06, 6.53 +/- 0.73, 0.81 +/- 0.08, 0.71 +/- 0.09, and 6.61 +/- 0.73 respectively, all P < 0.05).
Gene_expression (expression) of P-type Na+ -K+ -ATPase in trigeminal ganglion
5) Confidence 0.60 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18956709 Disease Relevance 0.06 Pain Relevance 0
Ouabain caused [3H]norepinephrine release at concentrations that produced 80 to 90% inhibition of Na,K-ATPase activity.
Gene_expression (produced) of Na,K-ATPase
6) Confidence 0.50 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2993543 Disease Relevance 0 Pain Relevance 0.15
One important reason both for Anna and Mona to choose CAM was that they had experienced severe side effects from the conventional treatments which they had been given.
Gene_expression (choose) of Mona associated with complementary and alternative medicine
7) Confidence 0.08 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.46 Pain Relevance 0.40
Further evidence employing also cultured cortical neurons have shown that dysfunction of the Na+/K+ ATPase can result from an increased generation of ROS during cellular exposure to ceramide, serum deprivation and staurosporine [11].


Gene_expression (dysfunction) of Na+/K+ ATPase in neurons
8) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.86 Pain Relevance 0
ROLE OF Na+/K+ ATPase
Gene_expression (ROLE) of Na+/K+ ATPase in ROLE
9) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.40 Pain Relevance 0

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