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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2011
Negated 5
Speculated 3
Reported most in Abstract
Documents 223
Total Number 226
Disease Relevance 154.78
Pain Relevance 49.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 37
blood 8
plasma 7
white blood cell 7
platelet 4
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 555 100.00 Very High Very High Very High
Glutamate 114 100.00 Very High Very High Very High
cytokine 22 100.00 Very High Very High Very High
abdominal pain 73 99.92 Very High Very High Very High
Pain 75 99.90 Very High Very High Very High
Inflammation 199 99.82 Very High Very High Very High
ischemia 54 99.68 Very High Very High Very High
adenocard 11 99.50 Very High Very High Very High
headache 38 99.48 Very High Very High Very High
Bile 125 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 376 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 73 100.00 Very High Very High Very High
Urological Neuroanatomy 8 100.00 Very High Very High Very High
Hepatitis 103 99.96 Very High Very High Very High
Congenital Anomalies 82 99.96 Very High Very High Very High
Jaundice 42 99.96 Very High Very High Very High
Hyperbilirubinemia 8 99.96 Very High Very High Very High
Hepatic Encephalopathy 7 99.96 Very High Very High Very High
Diabetes Mellitus 124 99.94 Very High Very High Very High
Fever 89 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paracetamol (7 g/kg) and chloroquine (970 mg/kg) administration increased significantly the transaminase levels.
Positive_regulation (increased) of transaminase associated with paracetamol
1) Confidence 0.70 Published 2000 Journal Indian J. Exp. Biol. Section Abstract Doc Link 11395959 Disease Relevance 0.16 Pain Relevance 0.64
Glutamic oxalacetic acid transaminase (GOT) activity in plasma increased in rats receiving 500 mg kg-1 paracetamol.
Positive_regulation (increased) of GOT in plasma associated with paracetamol
2) Confidence 0.69 Published 1992 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1361541 Disease Relevance 0 Pain Relevance 0.39
Oleanolic acid checked the inflammation-induced increased serum transaminase levels.
Positive_regulation (increased) of serum transaminase associated with inflammation
3) Confidence 0.68 Published 1992 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1359067 Disease Relevance 0.81 Pain Relevance 0.27
It inhibited inflammation induced increase in serum transaminase levels and leucocyte counts but lacked any analgesic or anti-pyretic effects.
Positive_regulation (increase) of serum transaminase in leucocyte associated with inflammation and analgesic
4) Confidence 0.67 Published 1986 Journal Agents Actions Section Abstract Doc Link 3751752 Disease Relevance 0.81 Pain Relevance 0.36
It is characterized by striking elevation of transaminase levels and the potential for acute liver failure with high morbidity and mortality rates.
Positive_regulation (elevation) of transaminase in liver associated with acute liver failure
5) Confidence 0.65 Published 2000 Journal Postgrad Med Section Abstract Doc Link 10649673 Disease Relevance 0.45 Pain Relevance 0.33
When pregnant woman has nausea or vomiting, abdominal pain and jaundice, increased transaminase activity, coagulopathy and hypoglycemia during third trimester AFLP should be suspected.
Positive_regulation (increased) of transaminase associated with hypoglycemia, coagulation disorder, abdominal pain, vomiting and jaundice
6) Confidence 0.65 Published 1999 Journal Ginekol. Pol. Section Abstract Doc Link 10582407 Disease Relevance 0.94 Pain Relevance 0.10
Diclofenac hepatotoxicity ranges from asymptomatic elevation of transaminase activity to significant liver disease. 31 cases of diclofenac-induced hepatitis with five associated deaths have been already reported in the English, French and Spanish literature.
Positive_regulation (elevation) of transaminase in liver associated with liver disease, hepatotoxicity, diclofenac and hepatitis
7) Confidence 0.65 Published 1998 Journal Z Gastroenterol Section Abstract Doc Link 9654706 Disease Relevance 0.94 Pain Relevance 0.54
Four cases, who had anethesia with GOF, revealed the elevation of transaminase.
Positive_regulation (elevation) of transaminase
8) Confidence 0.65 Published 1983 Journal Jpn J Antibiot Section Abstract Doc Link 6573518 Disease Relevance 0 Pain Relevance 0.10
In all but two cases--thioacetamide and allyl alcohol--there was a good correspondence between chemicals active in the assay as now performed and those that elevate serum transaminase and cause liver injury on short-term exposure in vivo.
Positive_regulation (elevate) of transaminase in liver associated with injury and alcohol
9) Confidence 0.61 Published 1980 Journal J Toxicol Environ Health Section Abstract Doc Link 6991712 Disease Relevance 0.10 Pain Relevance 0.27
Glutamic pyruvic transaminase (SGPT) was significantly elevated to 776 (+/- 226) U/1 in the T3-treated rats (10 mg/kg/day, orally) immediately after halothane anesthesia.
Positive_regulation (elevated) of transaminase associated with anesthesia and halothane
10) Confidence 0.60 Published 1980 Journal Anesthesiology Section Abstract Doc Link 7377592 Disease Relevance 0.32 Pain Relevance 0.45
After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered.
Positive_regulation (elevation) of transaminase associated with glutamate
11) Confidence 0.60 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 7992815 Disease Relevance 0.17 Pain Relevance 0.19
After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered.
Positive_regulation (elevation) of transaminase associated with glutamate
12) Confidence 0.60 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 7992815 Disease Relevance 0.17 Pain Relevance 0.19
In amiodarone-treated patients, the major findings were as follows: a 50% incidence of hepatic dysfunction with a tenfold increase in concentrations of serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase; a 25% incidence of pulmonary dysfunction necessitating a fourfold increase in the number of days of ventilator support; and a 19% incidence of low cardiac output syndrome with two deaths.
Positive_regulation (increase) of transaminase associated with hepatotoxicity and low cardiac output
13) Confidence 0.58 Published 1989 Journal Ann. Thorac. Surg. Section Abstract Doc Link 2774719 Disease Relevance 0.34 Pain Relevance 0.10
In amiodarone-treated patients, the major findings were as follows: a 50% incidence of hepatic dysfunction with a tenfold increase in concentrations of serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase; a 25% incidence of pulmonary dysfunction necessitating a fourfold increase in the number of days of ventilator support; and a 19% incidence of low cardiac output syndrome with two deaths.
Positive_regulation (increase) of transaminase associated with hepatotoxicity and low cardiac output
14) Confidence 0.58 Published 1989 Journal Ann. Thorac. Surg. Section Abstract Doc Link 2774719 Disease Relevance 0.34 Pain Relevance 0.10
In persons with diabetes who have elevated hepatic transaminase levels, it is important to search for other causes of liver disease, including hepatitis and hemochromatosis.
Positive_regulation (elevated) of transaminase in liver associated with liver disease, diabetes mellitus, iron overload and hepatitis
15) Confidence 0.57 Published 2008 Journal Am Fam Physician Section Abstract Doc Link 18619079 Disease Relevance 2.36 Pain Relevance 0.21
METHODS: Questionnaires mailed to the medical directors of 76 poison centres in North America and 48 poison centres in Europe asked respondents to comment on the management of a hypothetical case of a child who had received repeated doses of paracetamol at a daily dose of 90 mg/kg during a febrile illness and who presented to the emergency department with mildly elevated serum transaminase levels.
Positive_regulation (elevated) of transaminase
16) Confidence 0.56 Published 2002 Journal Drug Saf Section Body Doc Link 12113645 Disease Relevance 0.07 Pain Relevance 0
Clinicians must have a high index of suspicion for this condition when a woman has nausea or vomiting, abdominal pain (particularly epigastric), jaundice, polyuria-polydipsia (without diabetes), increased serum transaminase activity or thrombocytopenia in late pregnancy.
Positive_regulation (increased) of transaminase associated with polyuria, abdominal pain, diabetes mellitus, vomiting, thrombocytopenia and jaundice
17) Confidence 0.56 Published 1998 Journal Semin. Perinatol. Section Abstract Doc Link 9638907 Disease Relevance 1.12 Pain Relevance 0.10
There were no serious complications with adequate pharmacological cover, however, a transient fever, leucocytosis, abdominal pain and an increase in serum transaminase activities occurred after the procedure.
Positive_regulation (increase) of transaminase associated with abdominal pain and fever
18) Confidence 0.56 Published 1986 Journal Dtsch Z Verdau Stoffwechselkr Section Abstract Doc Link 2424713 Disease Relevance 0.87 Pain Relevance 0.10
In contrast, patients included in the drug-free program appear to have a higher increase in serum transaminase levels than those treated with methadone or naltrexone (146.1 +/- 122.29 vs 91.88 +/- 81.96 and 86.99 +/- 64.26 Ul/ml, respectively).
Positive_regulation (increase) of transaminase associated with methadone
19) Confidence 0.56 Published 1997 Journal Rev Clin Esp Section Abstract Doc Link 9411543 Disease Relevance 0.62 Pain Relevance 0.36
Hypoxic liver injury is defined as a massive, but transient, increase in serum transaminase levels due to an imbalance between hepatic oxygen supply and demand in the absence of other acute causes of liver damage.
Positive_regulation (increase) of transaminase in liver associated with hypoxia, injury and hepatotoxicity
20) Confidence 0.56 Published 2006 Journal Mayo Clin. Proc. Section Abstract Doc Link 16970220 Disease Relevance 1.04 Pain Relevance 0.10

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