INT26042

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 4.88
Pain Relevance 5.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
neurons 3
dendrites 1
mammary gland 1
spines 1
boutons 1
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 194 100.00 Very High Very High Very High
Glutamate receptor 186 100.00 Very High Very High Very High
Glutamate 256 99.96 Very High Very High Very High
Dorsal horn neuron 52 99.84 Very High Very High Very High
Inflammation 104 99.80 Very High Very High Very High
amygdala 48 99.68 Very High Very High Very High
Hippocampus 125 98.88 Very High Very High Very High
depression 21 98.16 Very High Very High Very High
Kinase C 4 97.70 Very High Very High Very High
Eae 116 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 104 99.80 Very High Very High Very High
Stress 175 99.68 Very High Very High Very High
Adhesions 10 99.04 Very High Very High Very High
Depression 21 98.16 Very High Very High Very High
Inflammatory Pain 112 97.08 Very High Very High Very High
Hypoxia 144 95.52 Very High Very High Very High
Hypersensitivity 66 93.48 High High
Drug Dependence 1 88.28 High High
Pain 28 72.32 Quite High
Hyperalgesia 4 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence that these puncta represented synaptic receptors was obtained with electron microscopy and by examining the association of GluR2- and GluR1-immunoreactive puncta with glutamatergic boutons (identified with vesicular glutamate transporters or markers for unmyelinated afferents).
GluR2 Spec (examining) Binding (association) of in boutons associated with glutamate and unmyelinated
1) Confidence 0.40 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.36
Prolonged activity blockade (1-3 days) with an AMPA receptor antagonist increased cell surface (synaptic and extrasynaptic) glutamate receptor 1 (GluR1) and GluR2 but not GluR3, as well as GluR1/2 co-localization on the cell surface and total GluR1 and GluR2 protein levels.
GluR2 Neg (not) Binding (blockade) of associated with glutamate receptor and antagonist
2) Confidence 0.30 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.09 Pain Relevance 0.58
Such a mechanism might also contribute to CFA-induced internalization of GluR2 subunits in vivo.
GluR2 Binding (internalization) of
3) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.46 Pain Relevance 0.49
We also found that GluR2 was markedly internalized in dorsal horn neurons at 24 h post-CFA injection.
GluR2 Binding (internalized) of in neurons associated with dorsal horn neuron
4) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.30 Pain Relevance 0.50
In addition, we show that CFA-induced peripheral inflammation leads to GluR2 internalization and GluR1 membrane insertion in dorsal horn neurons, without altering the expression and distribution of total GluR1 and GluR2 proteins in dorsal horn.
GluR2 Binding (internalization) of in dorsal horn associated with inflammation, dorsal horn and dorsal horn neuron
5) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 1.01 Pain Relevance 0.79
Similarly, Protein kinase C phosphorylation of GluR2 at Ser880 disrupts GluR2 binding to its synaptic anchoring protein ABP/GRIP and promotes GluR2 internalization in cultured hippocampal neurons [36,37].
GluR2 Binding (internalization) of in neurons associated with kinase c
6) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.45 Pain Relevance 0.47
However, electrophysiological recordings from GluN2 subunits carrying mutation in the NTD suggest a model in which NTDs of GluN1 and GluN2 heterodimerize [134].
GluN2 Binding (heterodimerize) of
7) Confidence 0.25 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.11
Based on drawing an analogy to the interaction between GluN2 and PSD-95, the interaction between GluA1 and SAP97 was identified by directly testing the interaction [90].
GluN2 Binding (interaction) of
8) Confidence 0.20 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.06
Consistently, stargazin/TARPs form a stable complex with GluR2 tetramers but not with the dimer intermediates during biogenesis.
GluR2 Binding (complex) of
9) Confidence 0.20 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0.17 Pain Relevance 0
Importantly, the latter two proteins co-purify with native AMPA-Rs without using chemical crosslinkers in stark contrast to the interaction between the GluA2 NTD and N-cadherin.
GluA2 Binding (interaction) of
10) Confidence 0.20 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.04
Stargazin preferentially forms a stable complex with GluR2 tetramers but not with dimers.
GluR2 Neg (not) Binding (complex) of
11) Confidence 0.20 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0
Previous work has shown that corticosterone facilitates the recruitment of GluA2-AMPARs by enhancing lateral diffusion, and increases both GluA2-AMPAR synaptic surface content and surface mobility in cultured hippocampal neurons [10], [11].
GluA2 Binding (recruitment) of in neurons
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.53 Pain Relevance 0.25
Thus, acute stress likely reduces GluA2 AMPAR internalization in the amygdala and in the VH, which predicts that acute stress would impede the generation of LTD in these regions.
GluA2 AMPAR Binding (internalization) of in amygdala associated with stress, hippocampus and amygdala
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.58 Pain Relevance 0.42
Accordingly, the NTDs and the TMDs were dimerized in the dimeric GluA2 wild-type, providing structural evidence for previously reported observations.
GluA2 Binding (dimerized) of
14) Confidence 0.19 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.03
However, it remains to be determined if the mutant GluA2 subunits that cannot bind to glutamate can transition into tetramers under similar experimental conditions in the absence of UPR.
GluA2 Neg (cannot) Binding (bind) of associated with glutamate
15) Confidence 0.19 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.13
When overexpressed in HEK cells, the mutant GluK2 subunits that cannot bind glutamate were detected as a mixture of monomer, dimer, tetramers, and high molecular weight misfolded aggregates, the latter being the majority [169].
GluK2 Neg (cannot) Binding (bind) of associated with glutamate
16) Confidence 0.16 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.05
, VEGF, nitric oxide synthase, and glutamate receptor subunits NMDAR1, GluR2, GluR3 were each found to be upregulated at 3 h and 24 h, but all returned to control levels by 14 days.
GluR2 Binding (found) of associated with glutamate receptor
17) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.00 Pain Relevance 0.12
Furthermore, the extracellular N-terminal domain of GluR2 can interact directly with the cell adhesion molecule N-cadherin to promote the formation and growth of dendritic spines [31], [32].
GluR2 Binding (interact) of in spines associated with adhesions
18) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.16 Pain Relevance 0.03
The antibodies used in this experiment bind to specific sites on the GluR1 (Ser831) and GluR2/GluR3 (C terminal) subunits and no cross-reactivity has been reported.
GluR2 Neg (no) Binding (bind) of
19) Confidence 0.08 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2638550 Disease Relevance 0 Pain Relevance 0
In the adult cerebellum, the glutamate receptor delta2 subunit (GluRdelta2) is selectively targeted to the spines of the distal Purkinje cell dendrites, the spiny branchlets, that are innervated by the parallel fibers.
GluRdelta2 Binding (targeted) of in dendrites associated with glutamate receptor
20) Confidence 0.08 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12657696 Disease Relevance 0 Pain Relevance 0.16

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