INT260508

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 2.60 Pain Relevance 0.14

molecular_function (Zfp941) cellular_component (Zfp941) biological_process (Zfp941)

Anatomy Link Frequency brain 2 spleen 1 Zfp941 (Mus musculus)

Pain Link Frequency Relevance Heat Eae 5 93.52 anesthesia 10 54.88 Inflammation 5 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 120 99.60 Sprains And Strains 45 98.28 Paresis 5 98.04 Scrapie 60 98.00 Disease 60 97.68 Congenital Anomalies 5 79.32 Infection 20 64.32 Death 5 52.92 Leukoencephalopathies 5 52.48 Drug Induced Neurotoxicity 5 36.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of PrPmyc in Tg941 was approximately 0.33 fold in brain and 2-fold in spleen of PrPC expression in Prnp+/o mice (data not shown).

Gene_expression (Expression) of Tg941 in spleen

1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.48 Pain Relevance 0.04

As Tg941 mice express about one-third of the PrPmyc found in brains of Tg940 mice, this indicates that the action of PrPmyc, like that of PrPC, is dose-dependent.

Gene_expression (express) of Tg941 in brains

2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.50 Pain Relevance 0

To obtain transgenic strains that only expressed PrPmyc yet no endogenous PrP, both transgenic founders Tg940 and Tg941 were crossed twice to Prnpo/o mice.

Gene_expression (crossed) of Tg941 associated with targeted disruption and sprains and strains

3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.61 Pain Relevance 0.05

Mice expressing less PrPmyc in brain (Tg941) developed signs of CNS dysfunction and terminal scrapie disease more slowly, at 316±20 (n?

Gene_expression (expressing) of Tg941 in brain associated with scrapie and disease

4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.65 Pain Relevance 0.05

The two highest-expressing lines, termed Tg(PrPmyc)940Zbz and Tg(PrPmyc)941Zbz (henceforth Tg940 and Tg941 for brevity) were chosen for further propagation.

Gene_expression (expressing) of Tg941

5) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.35 Pain Relevance 0

General Comments

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