INT260779

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
osteoblast 1
Bmp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 5.00 Very Low Very Low Very Low
Thoracotomy 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 4 99.96 Very High Very High Very High
Myocardial Infarction 153 99.20 Very High Very High Very High
Osteoporosis 14 98.68 Very High Very High Very High
Stress 1 86.52 High High
Teratoma 6 71.64 Quite High
Infarction 27 42.24 Quite Low
Congenital Anomalies 18 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Intervertebral Disk Degeneration 8 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of BMP-4 to Reduce CDE of MSC in vitro and in vivo
Negative_regulation (Inhibition) of BMP-4
1) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637970 Disease Relevance 0 Pain Relevance 0
At fused stage, early markers for osteoblasts and chondrocytes (runx2, osterix, sox9 and bmp2) were upregulated whereas the osteoblast inhibitor (twist) and genes involved in chondrocyte hypertrophy (bmp4, mef2c, col10a, shh and ihh) were downregulated, results also supported by ISH.
Negative_regulation (downregulated) of bmp4 in osteoblast associated with hypertrophy and osteoporosis
2) Confidence 0.18 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.46 Pain Relevance 0
These signaling pathways appear to act coherently in a time-dependent manner to bring about CD, since inhibition of one of the earliest upregulated molecules, BMP-4, is able to reduce MI repair in vivo or CD of MSCs in vitro.
Negative_regulation (inhibition) of BMP-4 associated with myocardial infarction
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637970 Disease Relevance 0.32 Pain Relevance 0
Collectively, these results corroborate that inhibition of BMP-4 leads to reduced CDE of MSCs both in vitro and in vivo, which is perhaps due to the fact that activation of BMP signaling is one of the earliest events in CD, as demonstrated by the activation of signaling pathways, on which full activation of other pathways and CD may depend.


Negative_regulation (inhibition) of BMP-4
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637970 Disease Relevance 0.17 Pain Relevance 0

General Comments

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