INT260917

From wiki-pain
Revision as of 20:27, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 4.10
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Anatomy Link Frequency
MDA-MB-231 2
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 17 99.12 Very High Very High Very High
Inflammation 465 61.96 Quite High
Arthritis 21 60.32 Quite High
cytokine 134 54.80 Quite High
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 21 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Inflammatory stimuli 12 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 577 99.90 Very High Very High Very High
Breast Cancer 20 98.88 Very High Very High Very High
Stress 15 98.40 Very High Very High Very High
Ovarian Cancer 8 94.56 High High
Colon Cancer 32 84.96 Quite High
Glioblastoma 4 73.92 Quite High
Lung Cancer 8 71.20 Quite High
INFLAMMATION 482 61.96 Quite High
Arthritis 17 60.32 Quite High
Hyperplasia 20 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overexpression of constitutively active MK2 results in increased HuR cytoplasmic localization in the MDA-MB-231 invasive breast cancer line [129].
Positive_regulation (increased) of Localization (localization) of HuR in MDA-MB-231 associated with breast cancer
1) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.18
Increased cytoplasmic localization of ELAVL1 protein is associated with increased oxidative stress and enhanced MAPKAPK2/3 phosphorylation (Lal et al., 2004; Raineri et al., 2004; Cherry et al., 2006).
Positive_regulation (Increased) of Localization (localization) of ELAVL1 protein associated with stress
2) Confidence 0.32 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.16 Pain Relevance 0.03
Certain signaling aberrations in cancer may promote cytoplasmic HuR localization such as p38 MAPK and PKC pathways.
Positive_regulation (promote) of Localization (localization) of HuR associated with kinase c and cancer
3) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.96 Pain Relevance 0.09
Several studies have pointed out that HuR is overexpressed in tumor cells when compared to their normal counterparts, with increased localization of HuR in cytoplasmic compartments.
Positive_regulation (increased) of Localization (localization) of HuR associated with cancer
4) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.90 Pain Relevance 0.03
How is cytoplasmic localization of HuR promoted in tumor cells?
Positive_regulation (promoted) of Localization (localization) of HuR associated with cancer
5) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.07 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox