INT261026

Context Info Confidence 0.36 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.88 Pain Relevance 0.06

cytosol (Gclc) ligase activity (Gclc)

Gclc (Rattus norvegicus)

Pain Link Frequency Relevance Heat methotrexate 1 58.40 Multiple sclerosis 4 53.72 Bioavailability 2 39.52 Glutamate 18 36.76 gABA 18 5.00 Dopamine 14 5.00 ischemia 8 5.00 Inflammation 7 5.00 imagery 7 5.00 cytokine 6 5.00

Disease Link Frequency Relevance Heat Stress 42 84.40 Pancreatitis 160 82.80 Mitochondrial Disorders 5 82.12 Cerebellar Diseases 9 72.92 Miller Fisher Syndrome 2 68.08 Sprains And Strains 16 58.88 Demyelinating Disease 5 53.72 Ataxia 73 50.04 Enteropathy 1 42.04 Celiac Disease 1 33.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, GCLC-reverse 5?

Localization (reverse) of GCLC

1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0 Pain Relevance 0

Therefore, quantitative real-time PCR was performed to monitor changes in GCLc and GCLm message abundance.

Localization (abundance) of GCLc

2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.39 Pain Relevance 0

NAC is rapidly hydrolyzed and under the consecutive effects of gamma-glutamylcysteine synthetase and GSH synthetase, GSH is generated.

Localization (generated) of gamma-glutamylcysteine synthetase

3) Confidence 0.11 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.49 Pain Relevance 0.06

General Comments

This test has worked.