INT261054

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.05

cell death (PLA2G6) cytoplasm (PLA2G6)

CHR (Homo sapiens) PLA2G6 (Homo sapiens)

Pain Link Frequency Relevance Heat Calcium channel 17 90.40 Inflammatory response 1 15.44 Inflammation 10 5.00 Catecholamine 6 5.00 imagery 4 5.00 medulla 4 5.00 Inflammatory stimuli 2 5.00 cytokine 1 5.00 Pain 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Death 1 81.92 Infection 2 54.76 INFLAMMATION 13 15.04 Apoptosis 2 5.00 Shock 2 5.00 Pain 1 5.00 Fungal Infection 1 5.00 Disease 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present experiments have demonstrated that the two CgA peptides, CHR and CAT, penetrate rapidly into PMNs (Figure 5A) and subsequently interact with CaM (Figure 5C) to activate iPLA2 (Figure 6C).

CHR Binding (interact) of iPLA2

1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.14 Pain Relevance 0.05

General Comments

This test has worked.