INT26115

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Context Info
Confidence 0.64
First Reported 1980
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 5.13
Pain Relevance 7.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
telencephalon 1
muscle 1
sympathetic 1
brainstem 1
hippocampus 1
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 85 100.00 Very High Very High Very High
Clonidine 22 100.00 Very High Very High Very High
Hyperalgesia 9 99.72 Very High Very High Very High
Hippocampus 20 99.26 Very High Very High Very High
Angina 4 98.28 Very High Very High Very High
Analgesic 20 97.52 Very High Very High Very High
Morphine 16 97.52 Very High Very High Very High
Serotonin 2 96.88 Very High Very High Very High
Antinociceptive 4 96.00 Very High Very High Very High
Dopamine 2 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 9 99.72 Very High Very High Very High
Neuropathic Pain 7 99.36 Very High Very High Very High
Diuresis 3 99.36 Very High Very High Very High
Obesity 101 98.44 Very High Very High Very High
Cv General 3 Under Development 4 98.28 Very High Very High Very High
Pain 1 93.32 High High
Targeted Disruption 1 91.20 High High
Aids-related Complex 1 89.40 High High
INFLAMMATION 48 89.04 High High
Drug Dependence 2 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single dose of 160 mg of long-acting propranolol can produce cardiac beta-adrenoceptor blockade throughout a 24 hr period without variability due to multiple peak concentrations.
Neg (without) Gene_expression (produce) of beta-adrenoceptor
1) Confidence 0.64 Published 1983 Journal Pharmacotherapy Section Abstract Doc Link 6361703 Disease Relevance 0.33 Pain Relevance 0.09
These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris.
Gene_expression (produces) of beta-adrenoceptor associated with angina
2) Confidence 0.57 Published 1980 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6156341 Disease Relevance 0.49 Pain Relevance 0.49
The development of neuropathic heat hyperalgesia required the presence of both the alpha(2A) adrenoceptor and the sympathetic postganglionic neuron (SPGN), but the development of mechanical hyperalgesia did not require either the alpha(2A) adrenoceptor or the SPGN, indicating different mechanisms of sensitization.
Gene_expression (presence) of adrenoceptor in sympathetic associated with hyperalgesia and neuropathic pain
3) Confidence 0.29 Published 2000 Journal Pain Section Abstract Doc Link 10781908 Disease Relevance 1.20 Pain Relevance 1.00
2-adrenoceptor specific
Gene_expression (specific) of adrenoceptor
4) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.67 Pain Relevance 0.40
-adrenoceptor stimulation
Gene_expression (stimulation) of adrenoceptor
5) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.41 Pain Relevance 0.41
The addition of NE (10(-8) to 10(-6) M) at the plateau of contraction produced by K+ (22.8 mM), histamine (10(-6) M) or acetylcholine (5 X 10(-8) M) produced a further phentolamine-sensitive contraction which was potentiated by beta adrenoceptor blockade with propranolol (10(-5) M).
Gene_expression (blockade) of adrenoceptor
6) Confidence 0.09 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3735137 Disease Relevance 0 Pain Relevance 0.09
Null mice for each of the three alpha(2) adrenoceptor subtypes (alpha(2A), alpha(2B), and alpha(2C)), and their wild-type cohorts, were tested for their antinociceptive and sedative response to N(2)O.
Gene_expression (three) of adrenoceptor associated with antinociceptive
7) Confidence 0.07 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11125002 Disease Relevance 0 Pain Relevance 0.79
Null mice for each of the three alpha(2) adrenoceptor subtypes (alpha(2A), alpha(2B), and alpha(2C)), and their wild-type cohorts, were tested for their antinociceptive and sedative response to N(2)O.
Gene_expression (each) of adrenoceptor associated with antinociceptive
8) Confidence 0.07 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11125002 Disease Relevance 0 Pain Relevance 0.79
-3 adrenoreceptor agonists induce expression of UCP1 not only in BAT, but also WAT.
Gene_expression (agonists) of adrenoreceptor associated with obesity and agonist
9) Confidence 0.06 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 1.37 Pain Relevance 0.11
The alpha-2 adrenoceptor agonists, clonidine, guanabenz, and guanfacine, injected subcutaneously produced a dose-related diuresis.
Gene_expression (produced) of adrenoceptor associated with diuresis, agonist and clonidine
10) Confidence 0.02 Published 1993 Journal Life Sci. Section Abstract Doc Link 8100606 Disease Relevance 0.17 Pain Relevance 0.52
The results showed alpha(2A) as the predominant alpha(2)-adrenoceptor subtype in the chicken brain while alpha(2B)- and/or alpha(2C)-adrenoceptor subtypes were detected only in the telencephalon.
Gene_expression (detected) of adrenoceptor in telencephalon
11) Confidence 0.01 Published 2006 Journal Neuroscience Section Abstract Doc Link 16697114 Disease Relevance 0.09 Pain Relevance 0.29
Chronic (but not acute) morphine downregulated mRNA levels of alpha(2A)- and alpha(2C)-adrenoceptors in the hippocampus, while simultaneously increased the expression of the alpha(2B)-adrenoceptor gene.
Gene_expression (expression) of adrenoceptor gene in hippocampus associated with hippocampus and morphine
12) Confidence 0.01 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.22 Pain Relevance 1.24
In addition, drug effects on alpha(2)-adrenoceptor gene expression were determined by real time RT-PCR in the hippocampus, a brain area that receives noradrenergic input from the brainstem.
Gene_expression (expression) of adrenoceptor gene in brainstem associated with medulla and hippocampus
13) Confidence 0.01 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.17 Pain Relevance 1.06
To identify the cyclooxygenase (COX) isozyme that catalyzes the production of this PGE(2) and the adrenoceptor (AR) subtype that mediates this effect, we microdialyzed for 6 h NE, cirazoline (alpha(1)-AR agonist), and clonidine (alpha(2)-AR agonist) into the POA of conscious guinea pigs pretreated intrapreoptically (intra-POA) with SC-560 (COX-1 inhibitor) or nimesulide or MK-0663 (COX-2 inhibitors) and measured the animals' core temperature (T(c)) and intra-POA PGE(2) responses.
Gene_expression (production) of adrenoceptor in POA associated with agonist, cox-2 inhibitor and clonidine
14) Confidence 0.00 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14962823 Disease Relevance 0 Pain Relevance 0.33
However, the atypical Schild regression of idazoxan after partial alkylation with phenoxybenzamine indicated the existence of a second alpha adrenoceptor site in the rat anococcygeus muscle.
Gene_expression (existence) of adrenoceptor site in muscle
15) Confidence 0.00 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2547934 Disease Relevance 0 Pain Relevance 0.17

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