INT261360

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.85
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
neuronal 1
perineum 1
cleavage 1
reticulum 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
depression 33 99.38 Very High Very High Very High
Hippocampus 18 99.26 Very High Very High Very High
antidepressant 85 98.68 Very High Very High Very High
Inflammation 6 97.00 Very High Very High Very High
Neurotransmitter 8 89.48 High High
Pain 26 88.00 High High
Kinase C 1 72.56 Quite High
Morphine 56 61.16 Quite High
Desipramine 3 52.80 Quite High
Disease Link Frequency Relevance Heat
Stress 22 99.48 Very High Very High Very High
Depression 74 99.38 Very High Very High Very High
Schizophrenia 220 98.86 Very High Very High Very High
Colon Cancer 21 98.28 Very High Very High Very High
Hypospadias 3 98.16 Very High Very High Very High
INFLAMMATION 5 97.00 Very High Very High Very High
Stress Incontinence 1 96.28 Very High Very High Very High
Convulsion 2 88.72 High High
Pain 27 88.00 High High
Death 9 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we found that one p75NTR missense polymorphism (S250L) was associated with the antidepressant response,53 and TrkB genetic variants may interact with the BDNF Val66Met polymorphism to contribute to the risk of geriatric depression.54 We also found that SNPs in glycogen synthase kinase-3beta (GSK3B), an important component in BDNF signaling, were associated with the therapeutic effects of antidepressants.55 In another study, we showed that genetic variants in plasminogen activator inhibitor type 1 gene (SERPINE1), which may be involved in the cleavage of proBDNF to mature BDNF in the brain,56 are related to MDD susceptibility and also the acute therapeutic response to antidepressants.57
glycogen synthase kinase-3beta Binding (associated) of in cleavage associated with antidepressant and depression
1) Confidence 0.36 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.24 Pain Relevance 0.48
-catenin-Lef (lymphoid enhancer-binding factor) complex acts as a crucial regulators of COX-2 mRNA, protein and PGE2 expression [22].
factor Binding (binding) of
2) Confidence 0.10 Published 2010 Journal Nutr J Section Body Doc Link PMC2868780 Disease Relevance 0.65 Pain Relevance 0.10
XBP1 is a an endoplasmic reticulum (ER) stress-responsive transcription factor regulating major histocompatibility complex (MHC) class II genes by binding to a promoter [206].
factor Binding (binding) of in reticulum associated with stress
3) Confidence 0.08 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.32 Pain Relevance 0.04
Moreover, estrogens play a role in activation of the molecular cascade involved in plastic adjustment of cellular functions inducing c-Fos expression (one of the first signs of neuronal plasticity) in the hippocampus [22], activate MAP-kinase (a growth factor) [23] and potentiate glutamate binding to N-methyl-d-aspartate (NMDA) receptors [20,21].
factor Binding (binding) of in neuronal associated with glutamate and hippocampus
4) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.34 Pain Relevance 0.29
One recent theory has proposed that factors involved in the normal development of sexual dimorphisms in the human brain may also interact with risk factors associated with schizophrenia.4 As these dimorphisms develop at the same critical fetal stages associated with schizophrenia vulnerability, research on factors that influence sexual dimorphisms was suggested for future schizophrenia research.4 That schizophrenia and abnormal sexual development share at least one risk factor associated with endocrine disruption is demonstrated by hypospadias, the abnormality in which the male urethra opens on the underside of the penis or on the perineum.
factor Binding (associated) of in perineum associated with stress incontinence, hypospadias and schizophrenia
5) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.30 Pain Relevance 0

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