INT26175

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 1989
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC, GCG) cytoplasm (POMC, GCG) extracellular space (POMC, GCG)
signal transduction (POMC, GCG) extracellular region (POMC, GCG) cell-cell signaling (POMC)
Anatomy Link Frequency
B cells 1
POMC (Homo sapiens)
GCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 98.56 Very High Very High Very High
aspirin 2 25.00 Low Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 7 97.40 Very High Very High Very High
Hyperinsulinism 1 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data confirm that beta-endorphin stimulates glucagon and inhibits basal and glucose-stimulated insulin secretion and suggest that the opioid influences the intraislet adenylate cyclase activity.
beta-endorphin Positive_regulation (stimulates) of glucagon associated with opioid
1) Confidence 0.47 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2551176 Disease Relevance 0.06 Pain Relevance 0.10
Acute insulin and glucagon responses to arginine were not increased by beta-endorphin, suggesting that the effect of the opioid on the B cells of the diabetic patients is specific for glucose.
beta-endorphin Neg (not) Positive_regulation (increased) of glucagon in B cells associated with diabetes mellitus and opioid
2) Confidence 0.30 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2951394 Disease Relevance 0.51 Pain Relevance 0.19

General Comments

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