INT261750

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.48 Pain Relevance 0.25

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6) cytoplasm (Stat6) signal transducer activity (Stat6)

Anatomy Link Frequency embryo 2 Stat6 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 48 74.52 Inflammation 4 66.04 ketamine 4 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 8 89.60 Asthma 42 70.24 INFLAMMATION 4 66.04 Pulmonary Eosinophilia 2 42.96 Hypersensitivity 6 40.12 Disease 6 5.00 Stress 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Disruption of the IL-4Ra gene can prevent the phosphorylation of STAT-6 caused by either IL-4 or 13.

Negative_regulation (prevent) of Phosphorylation (phosphorylation) of STAT-6

1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.48 Pain Relevance 0.16

This seems unlikely as the positive controls (both embryo and adult) still showed phosphorylation of STAT-6 at the same 1 hour time point.

Negative_regulation (showed) of Phosphorylation (phosphorylation) of STAT-6 in embryo

2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0.09

General Comments

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