INT261752

Context Info Confidence 0.86 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0.04

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6) cytoplasm (Stat6) signal transducer activity (Stat6)

Anatomy Link Frequency embryos 1 Stat6 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 24 81.60 ketamine 2 5.00 Inflammation 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Asthma 21 52.64 Pulmonary Eosinophilia 1 50.04 Targeted Disruption 4 5.00 Disease 3 5.00 Hypersensitivity 3 5.00 INFLAMMATION 2 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is possible that even if transplacental passage of IL-4 or 13 occurred, phosphorylated STAT-6 may have already degraded by the time the embryos were harvested, leading to a false negative.

Protein_catabolism (degraded) of STAT-6 in embryos

1) Confidence 0.86 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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