INT261790

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.41

plasma membrane (SHC1, Slc12a5) mitochondrion (SHC1) aging (SHC1) intracellular (Slc12a5) transmembrane transport (Slc12a5) cytoplasm (SHC1)

SHC1 (Homo sapiens) Slc12a5 (Rattus norvegicus)

Pain Link Frequency Relevance Heat bDMF 10 96.00 Limbic system 1 80.68 Neuronal excitability 1 75.92 Hippocampus 11 28.84 Glutamate receptor 2 24.60 tetrodotoxin 3 23.64 sodium channel 1 21.56 gABA 36 12.44 agonist 6 5.00 anticonvulsant 5 5.00

Disease Link Frequency Relevance Heat Stress 2 59.84 Convulsion 30 50.00 Epilepsy 22 5.00 Status Epilepticus 3 5.00 Hypoxia 2 5.00 Injury 2 5.00 Neurological Disease 1 5.00 Hepatic Encephalopathy 1 5.00 Syndrome 1 5.00 Targeted Disruption 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

signaling downregulates whereas Shc signaling upregulates KCC2 in their system [263].

Shc Positive_regulation (upregulates) of KCC2

1) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.06 Pain Relevance 0.41

General Comments

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