INT261841

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1) cytoplasm (Mastl)
mitosis (Mastl) nucleus (Mastl) cytoskeleton (Mastl)
Anatomy Link Frequency
smooth muscle 1
neurons 1
Mastl (Mus musculus)
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 6 100.00 Very High Very High Very High
nociceptor 92 97.28 Very High Very High Very High
qutenza 46 96.00 Very High Very High Very High
burning pain 4 93.40 High High
Pain 184 58.00 Quite High
Mechanotransduction 2 54.88 Quite High
Arthritis 4 48.72 Quite Low
Multiple sclerosis 2 47.84 Quite Low
Hyperalgesia 32 46.72 Quite Low
bradykinin 10 45.40 Quite Low
Disease Link Frequency Relevance Heat
Pain 192 93.40 High High
Sleep Disorders 2 69.12 Quite High
Dyspnea 2 68.56 Quite High
Cough 6 66.88 Quite High
Airway Obstruction 2 66.32 Quite High
Targeted Disruption 46 62.04 Quite High
Cancer 8 49.92 Quite Low
Arthritis 4 48.72 Quite Low
Demyelinating Disease 2 47.84 Quite Low
Hyperalgesia 54 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
THC also activates TRPA1 in trigeminal neurons [94].
THC Positive_regulation (activates) of TRPA1 in neurons
1) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.48 Pain Relevance 0.60
THC, a cannabinoid, activates TRPA1 and is suggested to induce some of its biological effects, like dilation of hepatic or mesenteric arteries via activation of capsaicin-sensitive, CGRP-containing perivascular sensory nerve endings innervating the smooth muscle [247].
THC Positive_regulation (activates) of TRPA1 in smooth muscle associated with qutenza and cannabinoid
2) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.35 Pain Relevance 0.70

General Comments

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